The potential of induced pluripotent stem cells in the study and treatment of monogenic diabetes


Authors: Terézia Valkovičová 1;  Martina Škopková 1;  Ying Cai 3;  Juraj Staník 1,2;  Miriam Cnop 3;  Daniela Gašperíková 1
Authors‘ workplace: DIABGENE & Ústav experimentálnej endokrinológie, Biomedicínske centrum SAV, Bratislava 1;  Detská klinika LF UK a NÚDCH, Bratislava 2;  ULB Center for Diabetes Research, Université Libre de Bruxelles, Belgicko 3
Published in: Diab Obez 2021; 21(41): 7-15
Category:

Overview

MEHMO and Wolfram syndrome are monogenic diseases, whose one of the clinical manifestations is nonautoimmune diabetes mellitus. Both are classified as a rare disease. Acquisition of the patients´ B-cells, that would be suitable for the study of the mechanisms leading to diabetes, is complicated or even impossible. However, new opportunities for diabetes studies are brought by the reprogramming of somatic patient cells into the stem cells and their subsequent differentiation into pancreatic B-cells. Such cells could be used also for cell therapy of the patients with both monogenic and polygenic types of diabetes.

Keywords:

human-induced pluripotent stem cell (hiPSC) – MEHMO – monogenic diabetes – Wolfram syndrome


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