Studies with SGLT2 inhibitors primarily focused on renal parameters in patients with chronic kidney disease with/without type 2 diabetes mellitus

Authors: Zbynek Schroner
Authors‘ workplace: SchronerMED s. r. o., Košice
Published in: Diab Obez 2021; 21(41): 35-38


At present are ongoing or finished some clinical studies with SGLT2 inhibitors primarely focused on renal outcomes in patients with chronic kidney disease (CKD) with or without type 2 diabetes mellitus. Canagliflozin in CREDENCE study in patients with type 2 diabetes mellitus and CKD stages 2–3b reduced risk of primary renal outcome (doubling of the serum creatinine level, end-stage kidney disease, death from renal or cardiovascular causes) by 30 % in comparison with placebo. Occurence of primary outcome – progression of CKD (defined as sustained decline in the estimated GFR of ≥ 50 % or end-stage kidney disease), or death from cardiovascular or renal causes – was by administration of dapagliflozin in study DAPA-CKD in patients with or without type 2 diabetes decreased by 39 %. Study EMPA-KIDNEY with empagliflozin is still ongoing. Current ADA/EASD guidelines recommend SGLT2 inhibitors in patients with CKD and GF ≥ 0,5 ml/s or albuminuria (mainly macroalbuminuria) as second line therapy after metformin independently of baseline or individualised HbA1c target.


canagliflozin – dapagliflozin – empagliflozin – study CREDENCE – study DAPA-CKD –study EMPA-KIDNEY

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Issue 41

2021 Issue 41

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