Discordance between blood glucose and HbA1c – is an explanation possible according to the biokinetic model of glycation?

Authors: Oliver Rácz 1;  Peter Dombrovský 1;  Vladimír Heriban 2;  Marek Brenišin 1;  Katarína Muriová 3
Authors‘ workplace: Ústav patologickej fyziológie LF UPJŠ v Košiciach 1;  Všeobecná zdravotná poisťovňa, a. s., Bratislava 2;  Nemocnica Poprad, a. s., Poprad 3
Published in: Diab Obez 2021; 21(41): 16-22


According to the biokinetic model of hemoglobin glycation, hyperglycemic episodes occured recently have a greater impact on HbA1c levels as compared with those occured long ago. In the first part of this paper there are theoretical calculations of HbA1c for stable blood glucose concentrations and for hyperglycemic episodes lasting 24 and 60 days occuring in different time before HbA1c measurement. The second part is devoted to analysis of discordance between blood glucose values and HbA1c assessed as glycation gap and glycation index in 158 patients with diabetes mellitus. The differences of HbA1c calculated according to the biokinetic model and timing of hyperglycemic episodes can probably explain the discordance between blood glucose values and HbA1c.


biokinetic model – diabetes mellitus – glycation index – glycation gap – HbA1c

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