Discordance between blood glucose and HbA1c – is an explanation possible according to the biokinetic model of glycation?

Czech version

Authors: Oliver Rácz ¹; Peter Dombrovský ¹; Vladimír Heriban ²; Marek Brenišin ¹; Katarína Muriová ³
Authors‘ workplace: Ústav patologickej fyziológie LF UPJŠ v Košiciach ¹; Všeobecná zdravotná poisťovňa, a. s., Bratislava ²; Nemocnica Poprad, a. s., Poprad ³
Published in: Diab Obez 2021; 21(41): 16-22
Category:

Overview

According to the biokinetic model of hemoglobin glycation, hyperglycemic episodes occured recently have a greater impact on HbA_1c levels as compared with those occured long ago. In the first part of this paper there are theoretical calculations of HbA_1c for stable blood glucose concentrations and for hyperglycemic episodes lasting 24 and 60 days occuring in different time before HbA_1c measurement. The second part is devoted to analysis of discordance between blood glucose values and HbA_1c assessed as glycation gap and glycation index in 158 patients with diabetes mellitus. The differences of HbA_1c calculated according to the biokinetic model and timing of hyperglycemic episodes can probably explain the discordance between blood glucose values and HbA_1c.

Keywords:

biokinetic model – diabetes mellitus – glycation index – glycation gap – HbA1c

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