When to search for inhereted thrombophilia risk factors in children?


Authors: J. Blatný
Authors‘ workplace: Oddělení dětské hematologie, FN Brno, primář MUDr. J. Blatný, Ph. D.
Published in: Čes-slov Pediat 2012; 67 (1): 60-63.
Category: Actual Topic

Overview

Incidence of venous thromboembolic events (VTE) in children has increased significantly over last twenty years. Published data however suggest, that inhereted prothrombotic risk factors play less significant role in paediatric venous thromboembolism, than originally supposed. Inhereted risk factors alone are deemed to be responsible for less than 15% of VTE in children.

Author critically reviews international as well as Czech national recommendations on indication of inhereted prothrombotic risk factors assesment in children.

Key words:
children, thrombosis, prothrombotic risk factors, hormonal contraceptives


Sources

1. Andrew M, David M, Adams M, et al. Venous thromboembolic (VTE) complications in children: first analyses of the Canadian registry of VTE. Blood 1994; 83: 1251–1257.

2. Yang J, Paredes N, Chan AK. Antithrombotic therapy in children with venous thromboembolism. Hamostaseologie 2009; 29(1): 80–87.

3. Vu LT, Nobuhara KK, Lee H, et al. Determination of risk factors for deep venous thrombosis in hospitalized children. J Pediatr Surg 2008; 43(6): 1095–1099.

4. Monagle P, Adams M, Mahoney M, et al. Outcome of pediatric thromboembolic disease: a report from the Canadian Childhood Thrombophilia registry. Pediatr Res 2000; 47: 763–766.

5. Antithrombotic and thrombolytic therapy, 8th ed. ACCP Guidelines. Chest 2008; 133(Suppl): 67S–968S.

Labels
Neonatology Paediatrics General practitioner for children and adolescents

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Czech-Slovak Pediatrics

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2012 Issue 1

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