Authors: D. Tegzová; K. Pavelka; K. Šírová; V. Vlasáková Authors‘ workplace: Revmatologický ústav, Praha, ředitel doc. MUDr. K. Pavelka, CSc. Soukromá revmatologická ambulance, OstravaInterní oddělení nemocnice, České Budějovice, přednosta MUDr. P. Havránek Published in: Čes. Revmatol., , 1999, No. 2, p. 79-84. Category:
Objective: The objective of the research project was to evaluate the effect of combined therapy withmethotrexate and cyclosporin A in active rheumatoid arthritis refractory to previous monotherapywith methotrexate, and to evaluate the incidence of undesirable effects of this treatment. Method:The investigated group comprised 37 patients with rheumatoid arthritis who were treated for atleast three months with methotrexate, at least 10 mg/week, with an unsatisfactory effect. Thesepatients were given in addition to the mentioned treatment cyclosporin, initial dose 2.5 mg/kg,gradually increasing up to 5 mg/day. The authors evaluated the trend of some parameters (erythro-cyte sedimentation rate, CRP, articular index, HAQ questionnaire) during six months treatment andinvestigated also the development of possible side effects. After completion of the study a completecheck-up examination after another six months was made and the further development of the diseaseand treatment was described in some patients. Results: In all investigated parameters there wasa significant drop as compared with values at the onset of treatment (p
Key words: rheumatoid arthritis, DMARDs, cyclosporin A, methotrexate
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