Clinical Correlations of AntinuclearAutoantibodies in Scleroderma

Authors: J. Štork 1;  J. Vencovský 2;  J. Kafková 2;  R. Bečvář 2
Authors‘ workplace: Kožní klinika 1. LF UK, VFN, Praha, přednosta prof. MUDr. F. Vosmík, DrSc. 2 Revmatologický ústav, Praha, ředitel doc. MUDr. K. Pavelka, CSc.
Published in: Čes. Revmatol., , 1999, No. 2, p. 67-71.


Clinical correlations of antinuclear antibodies (ANA) were studied in a group of 69 patients (7 men)with systemic sclerosis (SSc) or sclerodermic overlap syndrome (SOS) and undifferentiated connec-tive tissue disease (UCTD) as well as in a group of 23 patients (6 men) with morphea. Detection ofANA was performed by indirect immunofluorescence on HEp-2 cells (IF) and by immunoblotting onnuclear extracts from HeLa cells (IB). ANA were present in 98% of patients with SSc and 100% withSOS. Anticentromere antibodies (ACA) were found in 4% of SSc patients (strict criteria), in 10% ofSSc patients when less strict criteria were applied, and in 11% of all patients with systemicinvolvement. Anti-Scl-70 antibodies were present in 73% of SSc patients and in 63% of all patientswith the systemic form. Neither of the two antibodies showed any clinical correlation. Otherantibodies were detected by IB (anti: SSA/Ro, SSB/La, fibrilarin, RA33, Jo-1, PM-Scl and nRNP)which showed some tendency of association with organ involvement. The low frequency of ACA andthe high frequency of anti-Scl-70 could be a selection bias of patients to referral center. However noclinical correlations were observed, suggesting demographic differences between sclerodermapatients. In morphea, ANA were present in 69% (IF) and in 60% (IB). The latter were of unknownspecificity with the exception of one ACA positive patient with suspected transition to SSc.

Key words:
systemic sclerosis, morphea, antinuclear antibodies, anticentromere, anti-Scl-70

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Dermatology & STDs Paediatric rheumatology Rheumatology
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account