Validation of the ISK Question-naire (Index of Severity of Knee OA) in Czech within the Framework of the Trial on Administrationof Chondroitin Sulphate in Painful Knee Arthritis

Authors: K. Pavelka;  M. Olejárová;  A. Sainerová;  J. Vencovský
Authors‘ workplace: Revmatologický ústav, Praha, ředitel doc. MUDr. K. Pavelka, CSc.
Published in: Čes. Revmatol., , 1999, No. 2, p. 72-78.


The authors prepared a Czech version of the ISK (Lequesne) questionnaire. The questionnaire wasindependently translated by three doctors, followed by discussion of the translation and adoptionof the final version. The latter was retranslated into English. This questionnaire was tested as to itsreliability, the intra-reliability being 0.98 and evaluation by several examiners 0.97. The validitywas tested by means of a double blind controlled trial where a correlation between ISK and pain onthe visual analogue scale was demonstrated. The correlation was significant at the onset of the trial(r = 0.38), at the end of the trial (r = 0.73) and correlated with changes in the course of treatment(r = 0.64). In this double blind randomized controlled study the authors compared the symptomaticeffect of three different doses of chondroitin sulphate (CS) and placebo (CS 200 mg, CS 800 mg andCS 1200 mg/day). Doses of 800 mg and 1200 mg were more effective than 200 mg and placebo. Thedifferences were apparent from the 42 nd day of treatment onwards. The dose of CS 1200 mg was notmore effective than 800 mg. Evidence was provided that the Czech version is sufficiently reliableand valid for use in trials, routine practice and for assessment of patients with knee arthritis.

Key words:
gonarthritis, chondroitin sulphate, questionnaire

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Dermatology & STDs Paediatric rheumatology Rheumatology
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account