Authors: M. Lubušký 1; M. Procházka 1; J. Šantavý 2; I. Míčková 2; Š. Machač 1; L. Kantor 3 Authors‘ workplace: Gynekologicko-porodnická klinika LF UP a FN, Olomouc, přednosta prof. MUDr. M. Kudela, CSc. 1; Ústav lékařské genetiky a fetální medicíny LF UP a FN, Olomouc, přednosta prof. MUDr. J. Šantavý, CSc. 2; Novorozenecké oddělení LF UP a FN, Olomouc, primář MUDr. L. Kantor 3 Published in: Ceska Gynekol 2005; 70(1): 27-29 Category: Original Article
Objective: To evaluate the utilisation measurements of peak systolic velocities in the middle cerebral artery (MCA-PSV) to predict fetal anemia in pregnancies complicated by alloimmune antibodies known to cause immunological hydrops.
Design: A prospective study.
Setting: Department of Obstetrics and Gynecology, University Hospital, Olomouc.
Methods: In 38 pregnancies at risk for fetal anemia due to maternal red-cell alloimmunization MCA-PSV had been assessed and fetal blood sampling for measurement of hemoglobin concentration was obtained subsequently, either by cordocentesis or at delivery.
Results: 66 examinations were performed at 19–37 week’s gestation. An MCA-PSV >1.5 MoM detected 100 % of severely anemic fetuses with a hemoglobin concentration
Conclusion: Middle cerebral artery peak systolic velocity is a highly sensitive non-invasive means for determining the degree of anemia. A Doppler interval of seven days is recommended.
Key words: fetal anemia, middle cerebral artery peak systolic velocity, Doppler, red cell alloimmunization, intrauterine transfusion
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