Fixed-dose combinations in dyslipidemy treatment


Authors: M. Vráblík
Authors‘ workplace: Centrum preventivní kardiologie, III. interní klinika 1. LF UK a VFN v Praze
Published in: Kardiol Rev Int Med 2016, 18(2): 98-103

Overview

Combination pharmacotherapy is frequently being used in patients at high cardiovascular risk due to an accumulation of risk factors. Potential and real drug-drug interactions represent one of the important barriers to implementing guideline-recommended treatment strategies, but even more important might be decreasing adherence. One of the most feasible options seems to be fixed-dose combinations that have been used for the treatment of arterial hypertension and diabetes for some time. There are a few fixed-dose combinations of lipid lowering drugs currently available, such as the statin + ezetimibe combo and, more recently, statin + fenofibrate. The option of fixed-dose combinations of a lipid lowering agent with another representative drug class will soon become available. This will result in a simplification of drug regime, leading to better adherence to pharmacological treatment and a consequent reduction of residual cardiovascular risk.

Keywords:
statins –  fibrates –  ezetimibe –  antihypertensives –  fixed-dose combinations –  residual risk –  dyslipidemia


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Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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