Fixed-dose combination therapy for hypertension


Authors: J. Špinar 1;  J. Vítovec 2;  L. Špinarová 2
Authors‘ workplace: Interní kardiologická klinika LF MU a FN Brno 1;  I. interní kardioangiologická klinika LF MU a FN u sv. Anny v Brně 2
Published in: Kardiol Rev Int Med 2016, 18(2): 85-93

Overview

We present an overview of current opinions on the position of fixed-dose combinations in the treatment of hypertension in line with the ESH/ ESC and the Czech Society for Hypertension guidelines of 2013. The most frequently recommended double combinations are a renin angiotensin system inhibitor (ACE-I or sartan) plus a calcium antagonist, a renin angiotensin system inhibitor plus a diuretic, or a calcium antagonist plus a diuretic. A fixed-dose combination of an ACE inhibitor (perindopril), a calcium channel blocker (amlodipine) and a diuretic (indapamide) was introduced in the Czech market in 2014. The main advantage of fixed combinations is improved patient compliance, leading to a better control of hypertension. A triple combination is required for good control of hypertension in about one third of patients.

Keywords:
hypertension –  fixed-dose combination –  triple combination


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Labels
Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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