Dapagliflozin and the DECLARE study – the future of treating diabetes mellitus?


Authors: J. Špinar;  R. Lábrová
Authors‘ workplace: Interní kardiologická klinika LF MU a FN Brno
Published in: Kardiol Rev Int Med 2016, 18(2): 119-124

Overview

SGLT2 – gliflozins are a possible new treatment of diabetes mellitus type 2. The mechanism of action is excretion of glucose by the kidneys. The first mortality clinical trial with SGLT2 empagliflozin was finished in 2015 and other studies are currently running. Dapagliflozin has a large clinical trial programme, and meta-analysis data from smaller studies have shown a decrease in cardiovascular endpoints. This effect is probably a result of several mechanisms: reduction in blood sugar; blood pressure lowering; reduction in weight; and a diuretic effect. DECLARE is an international clinical trial of dapagliflozin, which is also running in the Czech Republic; the suspected trial closure is in 2018-19. The dapagliflozin clinical trial programme does not only include diabetes mellitus type 2 patients, but also type 1, as well as pediatric patients.

Keywords:
dapagliflozin – DECLARE – mortality


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Labels
Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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