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Comparable Long-term Safety of Tofacitinib and Biologics in RA Treatment –⁠ Data from a US Registry

18. 11. 2021 Source: Arthritis

An analysis of the long-term safety profile of tofacitinib in real clinical practice was published in the journal of the American College of Rheumatology (ACR). Patients with rheumatoid arthritis (RA) who started treatment with tofacitinib showed a similar frequency of predefined adverse events of special interest compared to a cohort treated with biological disease-modifying antirheumatic drugs (bDMARDs).

Webinář SGLT2i v ESC HF Guidelines vs. reálná praxe

Webinar SGLT2i in ESC HF Guidelines vs. Real Practice

Dear Doctor, Boehringer Ingelheim, in collaboration with the 2nd Department of Internal Medicine -⁠ Department of Cardiology and Angiology, General University Hospital and 1st Faculty of Medicine,…
18. 11. 2021 Source: Heart Failure
Echokardiografie_srdce_monitoring_kardiomyopatie_angina_pectoris_septum_venózní_hypertenze

Mechanisms of Cardioprotective Effects of SGLT2 Inhibitors

Inhibitors of sodium-glucose cotransporter 2 (SGLT2i, gliflozins) are a relatively new group of medications used in the treatment of type 2 diabetes mellitus (T2DM). Their clinical use is supported…
18. 11. 2021 Source: Heart Failure
doktorka_dite_leukemia

Summary of Guidelines for the Diagnosis, Prevention, and Treatment of Invasive Fungal Infections in Pediatric Patients with Leukemia and Post Hematopoietic Stem Cell Transplantation

Invasive fungal diseases are a significant cause of morbidity and mortality among immunocompromised pediatric patients with leukemia and post-hematopoietic stem cell transplantation. During the 8th…
18. 11. 2021 Source: Anti-Infectives
farmacie_antibiotika_tablety_kapsle_pilulky

Basic Cardiovascular Benefits of the Oral Antidiabetic Medication Empagliflozin

Type 2 diabetes mellitus is one of the main risk factors for cardiovascular (CV) diseases. Empagliflozin is among the modern oral antidiabetic medications, and in 2015 it became a pioneer among…
18. 11. 2021 Source: Heart Failure
Operace_operačnísál_lékaři

Reversal of Dabigatran Effects with Idarucizumab in Patients Requiring Urgent Procedures: Subanalysis of the RE-VERSE AD Study

The effect of idarucizumab as a reversal agent in patients treated with dabigatran in situations requiring urgent surgery or other invasive procedures was evaluated in a subanalysis from the RE-VERSE…
18. 11. 2021 Source: Anticoagulant Treatment
statistiky business grafy kancelář práce studie

Safety of Dabigatran According to a Meta-Analysis of 7 Randomized Controlled Trials

Dabigatran is a direct thrombin inhibitor from the group of direct oral anticoagulants (DOACs), developed as an alternative to vitamin K antagonists. The aim of the recently published meta-analysis…
18. 11. 2021 Source: Anticoagulant Treatment
PL_preklad_studium_studie_vyzkum_data_zprava

Efficacy and Safety of Dual Bronchodilator Therapy for COPD –⁠ From Randomized Clinical Trials to Real-World Clinical Practice

Dual bronchodilator therapy (LAMA + LABA) represents one of the mainstays of treating chronic obstructive pulmonary disease (COPD). The aim of the recent systematic review presented below was to…
18. 11. 2021 Source: Treatment of Asthma and COPD
kapka krve cukr srdce cukrovka diabetes srdeční

Epidemiology, Pathophysiology, Diagnosis, and Treatment of Heart Failure in Patients with Diabetes

The proven benefit of one class of antidiabetic drugs –⁠ sodium-glucose cotransporter 2 inhibitors (SGLT2i; gliflozins) –⁠ in treating heart failure irrespective of diabetes presence, and their…
18. 11. 2021 Source: Cardiovascular Continuum
štítná žláza_léky_stetoskop

Subclinical Hypothyroidism Associated with the Use of Allopurinol? What the Results of a Large Multicenter Study Suggested

Allopurinol is a widely used drug for the treatment of hyperuricemia and gout. The retrospective study presented below investigated whether its long-term use is associated with an increased risk of…
18. 11. 2021 Source: Thyroid Disorders

Does the emergence of resistance to cetuximab mean ineffectiveness of all anti-EGFR antibodies?

Colorectal cancer (CRC) cells respond to targeted therapy in different ways. Besides the desired outcome of cell death, CRC cells can adapt and survive through changes in their genome. It is…
12. 11. 2021 Source: Colorectal Cancer
ATB léčba infekcí vyvolaných MDR bakteriemi /Webinář 2.11.2021

VIDEO: Antibiotic Treatment of Infections Caused by MDR Bacteria –⁠ Seminar Recording

Recording of a professional seminar on the topic of infections caused by MDR bacteria, which took place on November 2, 2021, at the Medical House in Prague.
11. 11. 2021 Source: Anti-Infectives
genetika_geny_screening

Genetic Profiling Transforms the Diagnosis and Treatment of Cancer Diseases

Genome sequencing provides doctors with more information about the causes of cancer diseases and changes the ways of treating tumors. Targeted therapy aimed at oncogenic mutations has brought…
11. 11. 2021 Source: Genetic Profile and Treatment of NSCLC
obezita_lide_ulice

Dosing of Enoxaparin in Morbidly Obese Patients

How to optimally dose enoxaparin in morbidly obese patients? This question was addressed by a randomized study, the results of which were published in the journal Annals of Pharmacotherapy.
11. 11. 2021 Source: Thromboprophylaxis
Psoriaza_loket_pacient_lékař

Is long-term treatment with ixekizumab sufficiently safe?

Psoriasis is a chronic inflammatory disease whose manifestations require long-term treatment. A poster presented at last year's European Academy of Dermatology and Venereology (EADV) congress…
8. 11. 2021 Source: Biological Treatment
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