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Treatment of COPD in Individuals with Alpha-1 Antitrypsin Deficiency

6. 12. 2021 Source: Deficiency of Alpha-1-Antitrypsin

A mutation in the gene for alpha-1 antitrypsin (AAT), leading to its deficiency (AATD), causes progressive irreversible destruction of lung tissue. Patients develop chronic obstructive pulmonary disease (COPD) and early emphysema. Several studies evaluating COPD treatment have excluded patients with AATD. The aim of the following systematic literature review was to find and analyze works that include patients with concurrent COPD and AATD and summarize key findings that may form the basis for treatment decisions.

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Can the Treatment of Hypertension Prevent Recurrence of Atrial Fibrillation?

Atrial fibrillation (Afib) is the most common serious heart rhythm disorder and is responsible for a significant portion of deaths in the population. Hypertension is the most common and potentially…

3. 12. 2021 Source: Sartans in the Treatment of Hypertension

Reduction of Risk of Hospitalizations for Heart Failure in Type 2 Diabetics

The EMPA-REG OUTCOME study already in 2015 highlighted one of the benefits of the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin, which is the reduction of the risk of hospitalization…

2. 12. 2021 Source: Heart Failure

Recommendations for Substitution Therapy with Immunoglobulins in Hemato-oncological Patients with Secondary Immunodeficiency –⁠ Expert Consensus According to the DELPHI Methodology

Substitution therapy with immunoglobulins is used not only for patients with primary immunodeficiencies. Below, we briefly summarize recommendations concerning hemato-oncological patients with secondary...

1. 12. 2021 Source: Primary and Secondary Immunodeficiencies

How Does Emicizumab Work in Obese Adults with Hemophilia A?

What is the annual bleeding rate and minimum concentration of emicizumab in obese adults with hemophilia A compared to non-obese individuals? Answers were sought by the authors of a pooled post hoc…

1. 12. 2021 Source: Quality Life Even with Hemophilia

Romiplostim in Routine Clinical Use among Patients with ITP in European Countries −⁠ Fresh Data Analysis

Data from randomized clinical trials have shown that romiplostim is an effective medication for many patients not only with acute or persistent immune thrombocytopenia (ITP) but also for much more…

30. 11. 2021 Source: Immune Thrombocytopenia

How TPO-RA Drugs Fared in Meta-Analyses of Safety and Efficacy in ITP Patients

Meta-analyses regarding the use of thrombopoietin receptor agonists (TPO-RA) evaluated their efficacy and safety in the treatment of primary immune thrombocytopenia over long-term follow-ups. What…

30. 11. 2021 Source: Immune Thrombocytopenia

Expanded Hemodialysis and Its Impact on Reducing Hospitalization Rates and Medication Usage

The number of patients with end-stage kidney disease is increasing. New approaches and technological advancements in recent decades have contributed to improving hemodialysis treatment. Does the use…

30. 11. 2021 Source: Chronic Kidney Disease

Efficacy of Brigatinib in Patients with Metastatic NSCLC −⁠ Real-World Clinical Data

The journal Lung Cancer published the results of a retrospective analysis of the efficacy of brigatinib in patients with ALK-positive metastatic non-small cell lung cancer (NSCLC) who participated in…

29. 11. 2021 Source: Non-Small Cell Lung Cancer

Monocyte Distribution Width Indicates Sepsis Regardless of Sepsis Etiology

Patients in intensive care units represent a high-risk population for the development of sepsis, which is one of the primary causes of mortality in these settings. The aim of the recently published…

29. 11. 2021 Source: Because

News in Laboratory Diagnostics of Early Sepsis −⁠ First Czech Experiences

Sepsis represents one of the most frequent causes of morbidity and mortality in critically ill patients. Laboratory markers play an important role in the diagnosis and prognosis of septic states. The…

29. 11. 2021 Source: Because

Final Analysis of the STASEY Study: How Did Emicizumab Perform in Prophylaxis of Hemophilia A Patients with FVIII Inhibitors?

The July virtual congress of the International Society on Thrombosis and Haemostasis (ISTH) 2021 offered a range of interesting topics. In its poster section, data from the multicenter single-arm…

29. 11. 2021 Source: Quality Life Even with Hemophilia

What does the analysis of the CHESS PAEDs study say about the relationship between physical activity and the frequency of bleeding events in children with hemophilia A?

Currently, there is limited published data addressing the relationship between physical activity and the occurrence of bleeding events in children with hemophilia A. To gain insights into this topic…

27. 11. 2021 Source: Quality Life Even with Hemophilia

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Prognostic Significance of the Location of Colorectal Cancer Metastases

An Austrian study presented at the ESMO 2020 conference analyzed the relationship between the localization of colorectal cancer (CRC) metastases and patient survival, the time of metastasis…

26. 11. 2021 Source: Colorectal Cancer

Effect of PCSK9 Inhibitors on Clinical Outcomes in Patients with Hypercholesterolemia –⁠ Meta-Analysis of 35 Randomized Controlled Trials

The authors from several American institutions examined the efficacy and safety of two proprotein convertase subtilisin/kexin type 9 (PCSK9i) inhibitors, alirocumab and evolocumab, in their work.…

25. 11. 2021 Source: Hypercholesterolemia

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