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HAE Junior Helps Improve the Quality of Life for Pediatric Patients

24. 11. 2021 Source: Hereditary Angioedema

Living with hereditary angioedema (HAE) brings chronic health issues, long-term psychological stress, and a lifelong threat of death. Initial symptoms of HAE appear during childhood or adolescence. Many patients, however, remain misdiagnosed for a long time. The patient organization HAE Junior strives for a better quality of life for patients with this condition by improving awareness and access to modern therapy.

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Early Effect of Once-a-Day Trazodone in the Treatment of Major Depressive Disorder

Most antidepressants have a delayed onset of action, reaching therapeutically effective levels only several weeks after the start of treatment. Trazodone is characterized by a specific mechanism of…
24. 11. 2021 Source: Depression and Anxiety
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Gene Therapy for Hemophilia A: What is the Expression of Factor VIII Using the Adeno-Associated Viral Vector SPK-8011?

The goal of gene therapy for hemophilia A is to safely transfer stable and durable expression of coagulation factor VIII (FVIII), which predictably improves the bleeding phenotype at the lowest…
24. 11. 2021 Source: Quality Life Even with Hemophilia
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Von Willebrand Disease in Women

Even in the context of gynecological issues, it is sometimes necessary to consider a hematological etiology of difficulties. The recommendations of the American College of Obstetricians and…
23. 11. 2021 Source: Von Willebrand Disease
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Biosimilar Drugs in Oncology

8 of the 10 most expensive drugs on the market are used in the treatment of cancer. Rising healthcare costs in recent decades have created a need to find strategies to limit these costs. Biosimilar…
22. 11. 2021 Source: Oncological Treatment
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Pharmacotherapy of Chronic Heart Failure with Reduced EF LV -⁠ Latest ESC Recommendations

The European Society of Cardiology (ESC) issued an update in 2021 for the diagnosis and treatment of heart failure. We summarize the essential points regarding the pharmacotherapy of chronic heart…
22. 11. 2021 Source: Chronic Heart Failure and Lipidology
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Administration of aPCC as a Prevention of Bleeding After Major Cardiac Surgical Procedures

The possibility of actively preventing severe bleeding after a major cardiac surgical procedure using cardiopulmonary bypass (CPB) by administering a concentrate of activated procoagulant complex…
22. 11. 2021 Source: Hemophilia
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Neutralizing Antibodies Against Emicizumab –⁠ Detailed Analysis Based on a Case Study

Japanese authors investigated the mechanism of reduced efficacy of emicizumab in an adult patient with hemophilia A and an inhibitor, whose treatment was discontinued due to repeated bleeding…
22. 11. 2021 Source: Hemophilia
nateklé oko kluk angioedém

HAE and its Management in Pediatric Patients

Hereditary angioedema (HAE) can be encountered in the emergency room as well as in specialist practices. Patients with this rare disease are often incorrectly diagnosed with other, more common conditions,...
19. 11. 2021 Source: Hereditary Angioedema
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HAE in the Otolaryngologist's Office: How to Handle a Laryngeal Attack?

Hereditary angioedema (HAE) can be encountered in emergency rooms and specialist offices. Patients with this rare disorder are often misdiagnosed with a more common condition, and they may learn their...
19. 11. 2021 Source: Hereditary Angioedema
revmatoidni artritida

Cell-Based Implant as a Stable System for Biological Therapy Delivery

A team of scientists from Washington University in St. Louis focused on the possibility of delivering biological inhibitors for the treatment of rheumatoid arthritis using modified induced…
19. 11. 2021 Source: Arthritis
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Comparable Long-term Safety of Tofacitinib and Biologics in RA Treatment –⁠ Data from a US Registry

An analysis of the long-term safety profile of tofacitinib in real clinical practice was published in the journal of the American College of Rheumatology (ACR). Patients with rheumatoid arthritis…
18. 11. 2021 Source: Arthritis
Webinář SGLT2i v ESC HF Guidelines vs. reálná praxe

Webinar SGLT2i in ESC HF Guidelines vs. Real Practice

Dear Doctor, Boehringer Ingelheim, in collaboration with the 2nd Department of Internal Medicine -⁠ Department of Cardiology and Angiology, General University Hospital and 1st Faculty of Medicine,…
18. 11. 2021 Source: Heart Failure
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Mechanisms of Cardioprotective Effects of SGLT2 Inhibitors

Inhibitors of sodium-glucose cotransporter 2 (SGLT2i, gliflozins) are a relatively new group of medications used in the treatment of type 2 diabetes mellitus (T2DM). Their clinical use is supported…
18. 11. 2021 Source: Heart Failure
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Summary of Guidelines for the Diagnosis, Prevention, and Treatment of Invasive Fungal Infections in Pediatric Patients with Leukemia and Post Hematopoietic Stem Cell Transplantation

Invasive fungal diseases are a significant cause of morbidity and mortality among immunocompromised pediatric patients with leukemia and post-hematopoietic stem cell transplantation. During the 8th…
18. 11. 2021 Source: Anti-Infectives
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