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News in Laboratory Diagnostics of Early Sepsis − First Czech Experiences
Sepsis represents one of the most frequent causes of morbidity and mortality in critically ill patients. Laboratory markers play an important role in the diagnosis and prognosis of septic states. The aim of the study by the Czech authors was to evaluate the diagnostic yield of new laboratory markers in the form of monocyte distribution width and specific markers on the surface of neutrophil granulocytes.
Final Analysis of the STASEY Study: How Did Emicizumab Perform in Prophylaxis of Hemophilia A Patients with FVIII Inhibitors?
The July virtual congress of the International Society on Thrombosis and Haemostasis (ISTH) 2021 offered a range of interesting topics. In its poster section, data from the multicenter single-arm…
What does the analysis of the CHESS PAEDs study say about the relationship between physical activity and the frequency of bleeding events in children with hemophilia A?
Currently, there is limited published data addressing the relationship between physical activity and the occurrence of bleeding events in children with hemophilia A. To gain insights into this topic…
Prognostic Significance of the Location of Colorectal Cancer Metastases
An Austrian study presented at the ESMO 2020 conference analyzed the relationship between the localization of colorectal cancer (CRC) metastases and patient survival, the time of metastasis…
Effect of PCSK9 Inhibitors on Clinical Outcomes in Patients with Hypercholesterolemia – Meta-Analysis of 35 Randomized Controlled Trials
The authors from several American institutions examined the efficacy and safety of two proprotein convertase subtilisin/kexin type 9 (PCSK9i) inhibitors, alirocumab and evolocumab, in their work.…
HAE Junior Helps Improve the Quality of Life for Pediatric Patients
Living with hereditary angioedema (HAE) brings chronic health issues, long-term psychological stress, and a lifelong threat of death. Initial symptoms of HAE appear during childhood or adolescence.…
Early Effect of Once-a-Day Trazodone in the Treatment of Major Depressive Disorder
Most antidepressants have a delayed onset of action, reaching therapeutically effective levels only several weeks after the start of treatment. Trazodone is characterized by a specific mechanism of…
Gene Therapy for Hemophilia A: What is the Expression of Factor VIII Using the Adeno-Associated Viral Vector SPK-8011?
The goal of gene therapy for hemophilia A is to safely transfer stable and durable expression of coagulation factor VIII (FVIII), which predictably improves the bleeding phenotype at the lowest…
Von Willebrand Disease in Women
Even in the context of gynecological issues, it is sometimes necessary to consider a hematological etiology of difficulties. The recommendations of the American College of Obstetricians and…
Biosimilar Drugs in Oncology
8 of the 10 most expensive drugs on the market are used in the treatment of cancer. Rising healthcare costs in recent decades have created a need to find strategies to limit these costs. Biosimilar…
Pharmacotherapy of Chronic Heart Failure with Reduced EF LV - Latest ESC Recommendations
The European Society of Cardiology (ESC) issued an update in 2021 for the diagnosis and treatment of heart failure. We summarize the essential points regarding the pharmacotherapy of chronic heart…
Administration of aPCC as a Prevention of Bleeding After Major Cardiac Surgical Procedures
The possibility of actively preventing severe bleeding after a major cardiac surgical procedure using cardiopulmonary bypass (CPB) by administering a concentrate of activated procoagulant complex…
Neutralizing Antibodies Against Emicizumab – Detailed Analysis Based on a Case Study
Japanese authors investigated the mechanism of reduced efficacy of emicizumab in an adult patient with hemophilia A and an inhibitor, whose treatment was discontinued due to repeated bleeding…
HAE and its Management in Pediatric Patients
Hereditary angioedema (HAE) can be encountered in the emergency room as well as in specialist practices. Patients with this rare disease are often incorrectly diagnosed with other, more common conditions,...
HAE in the Otolaryngologist's Office: How to Handle a Laryngeal Attack?
Hereditary angioedema (HAE) can be encountered in emergency rooms and specialist offices. Patients with this rare disorder are often misdiagnosed with a more common condition, and they may learn their...
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