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First mRNA Treatment for Glycogen Storage Disease Already in Testing Phase
Glycogen storage disease type Ia, also known as von Gierke disease, is a serious inherited disorder with an autosomal recessive inheritance pattern, caused by a deficiency of the enzyme glucose-6-phosphatase. Causal therapy has not been available so far, but this could change in the near future. In a clinical study, the first patient received mRNA therapy aimed at replacing the missing enzyme.
CASE STUDIES: Treatment Options for Wounds in Cancer Patients
Wounds arising due to generalized cancerous diseases or their treatments require specific procedures...
Risk of Venous Thromboembolism and CV Events during Targeted Treatment of Nonspecific Bowel Inflammations
Authors of a freshly published study based on real-world data from the USA investigated whether…
Comparison of the Efficacy of Tofacitinib and Vedolizumab in the Treatment of Ulcerative Colitis After Anti-TNF Therapy Failure
Therapeutic options for ulcerative colitis resistant to anti-TNF-α antibody treatment are…
Bone density in hemophiliacs − known and less-known risk factors
Osteopenia or osteoporosis are known comorbidities of hemophilia and concern many of these…
Turoctocog Alfa in Tertiary Prophylaxis of Hemophilia A or Is It Always About Bleeding? Case Studies
This case report from our own practice concerns our experience with the treatment of hemophilia A…
Nearly 20 Years with Bevacizumab Has Brought Hope for Patients and Deeper Understanding of Solid Tumors
Bevacizumab is among the first targeted therapies used in oncology. For many indications where…
Lurasidone in Antipsychotic Therapy – A Case Study of a Virtual Patient from the Laurie Project
MUDr. Elis Bartečků, Ph.D., from the Department of Psychiatry at MU LF and FN Brno presented the…
Complex Impacts of Obesity on the Brains of People with Psychiatric Disorders
Obesity in individuals with bipolar disorder or schizophrenia is closely linked not only to higher…
Time is Blood! Impact of Diagnostic Delays on Prognosis of Patients with Acquired Hemophilia A
The famous slogan of neurologists in connection with strokes – 'Time is brain!' – can be modified…
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