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Effect of Trifluridine/Tipiracil Combination Depending on Patient Prognosis

19. 6. 2020 Source: Treatment of Gastrointestinal Carcinomas

The results of the RECOURSE clinical study were published in 2015 and became an important basis for the approval of the trifluridine/tipiracil combination in the treatment of metastatic colorectal cancer (mCRC). The data obtained in this study were also subjected to several post-hoc analyses. One of these recently brought information on how patient prognosis affects the clinical outcomes of this treatment.

Impact of Vitamin D Deficiency on Inflammatory Cytokine Concentrations in Patients with Diabetic Foot Syndrome

Vitamin D deficiency is relatively common in the population. Vitamin D plays an important role, among other things, in the functioning of the immune system. The aim of the presented study was to determine...

18. 6. 2020 Source: Wound Healing

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Treatment with Osimertinib in Patients with NSCLC After Disease Progression on Previous Therapy –⁠ Case Study

We present a case study of a patient with non-small cell lung cancer (NSCLC) with a proven activating mutation of the epidermal growth factor receptor (EGFR) gene, who developed resistance to the…

16. 6. 2020 Source: Lung Cancer

Quality of Life in Patients with mCRC Treated with mFOLFOXIRI and Panitumumab

At the congress of the European Society for Medical Oncology (ESMO) in September 2019, the results of the VOLFI study were presented, which also monitored the quality of life in patients with…

16. 6. 2020 Source: Colorectal Cancer

Changes in Blood Count as Possible Prognostic Markers of Response to Panitumumab in Patients with mCRC

As part of the VALENTINO study with panitumumab in patients with metastatic colorectal cancer without RAS mutation, the connection between certain blood count parameters associated with inflammation…

16. 6. 2020 Source: Colorectal Cancer

Alzheimer's Disease: Diagnosis Step by Step in 4 Points

Alzheimer's disease is the most common cause of dementia. With the aging population, this topic is becoming increasingly relevant. How have the knowledge and diagnostic possibilities of the disease…

16. 6. 2020 Source: Cognitive in the treatment of Alzheimer's disease

Incidence of Allergic Diseases in Children Probably Unrelated to Air Pollution

A recently published extensive meta-analysis of 7 cohorts of children aged 4 and 8 from 5 European countries investigated the relationship between air pollution at the child's place of residence and…

12. 6. 2020 Source: Allergic Reactions

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Asthma is not a risk factor for a severe course of COVID-19

According to the statement of the Czech Initiative for Asthma from April 2020, the disease COVID-19 caused by the new type of coronavirus does not pose significantly greater danger for people with…

12. 6. 2020 Source: Asthma under control

“Think about the thyroid gland during pregnancy,” reminds awareness campaign

Thyroid disorders can endanger the health of both the fetus and the mother. Sometimes, however, the problem only manifests during pregnancy, and the expectant mother or her doctor might not notice it…

10. 6. 2020 Source: Thyroid Disorders

After 20 years, a new treatment option for primary biliary cholangitis arrives

Primary biliary cholangitis (PBC), formerly known as cirrhosis, is a rare disease with a negative impact on prognosis and quality of life. While ursodeoxycholic acid (UDCA) has been essentially the…

10. 6. 2020 Source: Primary Biliary Cholangitis

Osimertinib in the Treatment of Patients with NSCLC with Secondary EGFR T790M Mutation –⁠ Case Study

Non-small cell lung cancer (NSCLC) is a genetically heterogeneous disease. Individualization of therapy based on the presence of specific tumor cell mutations is therefore crucial for choosing the…

10. 6. 2020 Source: Lung Cancer

Chronic Thromboembolic Pulmonary Hypertension –⁠ Overview of Pathophysiology, Diagnosis, and Treatment

Chronic thromboembolic pulmonary hypertension (CTEPH) is defined by the 2015 ESC/ERS guidelines as symptomatic pulmonary hypertension with persistent defects in lung perfusion despite adequate…

9. 6. 2020 Source: Pulmonary hypertension (CTEPH, PAH)

Effect of Cataract Surgery on Melatonin Secretion in Adults Aged 60 and Over

A study by ophthalmologists and epidemiologists from Nara University in Japan, recently published in JAMA Ophthalmology, examined the relationship between cataract surgery, the use of clear and…

8. 6. 2020 Source: Glaucoma

Morning Myopic Shift and Glare in Patients with Advanced Fuchs Endothelial Corneal Dystrophy

A newly published study by a German team analyzes the morning and afternoon differences in various parameters in patients with Fuchs endothelial corneal dystrophy to determine which of them…

8. 6. 2020 Source: Glaucoma

Venetoclax in the Treatment of CLL: Open Doors for the Longest Possible Maintenance of Remission Without Active Therapy

William G. Wierda from MD Anderson Cancer Center in Houston, USA, and Francesco P. Tambaro from Azienda Ospedaliera di Rilievo Nazionale Santobono-Pausilipon in Naples, Italy, evaluate in their…

8. 6. 2020 Source: Chronic Lymphocytic Leukemia

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