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Efficacy of Reduced Dose Tumor Necrosis Factor Inhibitors in Axial Spondyloarthritis
The introduction of tumor necrosis factor inhibitors marked a breakthrough in the treatment of axial spondyloarthritis and other autoimmune diseases. One disadvantage of using these drugs can be increased susceptibility of patients to various infectious agents. The aim of the presented meta-analysis was therefore to determine whether a reduced dose of TNF inhibitors provides the same efficacy with a more favorable safety profile compared to the standard dosing regimen.
Effect of Combination of Dorzolamide with Timolol for Wet Age-Related Macular Degeneration
In some eyes with wet age-related macular degeneration (AMD), exudation does not stop despite frequent intravitreal injections of vascular endothelial factor blockers (anti-VEGF). Adjuvant therapy…
Minimum and Optimal Factor Levels in Physically Active Hemophiliacs
Authors of a recently published study attempted to determine the value of minimum and optimal levels of coagulation factors in patients with severe hemophilia who engage in physical activities.
Tolerability and Efficacy of Eye Drops with and without Preservatives − A Comparison in Routine Clinical Practice
Insufficient patient compliance due to intolerance of the ocular preparation is a major reason for changing treatment, such as switching to preservative-free drops. The aim of the international…
In vivo monitoring of corneal changes in patients treated with and without preservative-containing glaucoma medications
A study published last year by Italian authors monitored structural changes in the corneas of patients treated with preservative-free glaucoma medication for 3 years using confocal microscopy and…
Possibilities of Using a Topical Immunomodulator for Exacerbation of Atopic Eczema – Case Study
A 17-year-old high school student consulted a dermatologist due to the exacerbation of atopic eczema symptoms. The worsening occurred after dietary non-compliance and an acute upper respiratory tract…
Pregabalin Relieves Patients with Central Neuropathic Pain
Treatment of central neuropathic pain, whether caused by spinal cord or cerebral damage, is often lengthy and not always successful. Study results show that pregabalin may be a suitable alternative…
Pregabalin in Seniors Confirmed Its Safety and Effectiveness
A pooled analysis of 11 studies investigated the safety and effectiveness of pregabalin in seniors with neuropathic pain. Are the outcomes in these indicators different for older individuals than in…
Induction vs. Escalation Treatment: Which Strategy to Choose in the Therapy of Multiple Sclerosis?
Opinions on the optimal therapy for multiple sclerosis (MS) are constantly evolving, and experts are debating the most appropriate first-line treatment strategy. A British cohort study focused on the…
Brodalumab in the Treatment of Psoriasis Symptoms on the Scalp and Nails
A post-hoc analysis of 3 clinical studies (AMAGINE-1/-2/-3) evaluates the effect of treatment with brodalumab or ustekinumab (compared to placebo) in patients with mild to severe psoriasis on the…
IPFchecker Project Helps Detect Patients with Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis is a serious progressive disease of the lung tissue of unclear etiology. Highly effective antifibrotic therapy is used in treatment, which can significantly prolong the…
Options for Anticoagulant Therapy During Catheter Ablation for Atrial Fibrillation: Safety and Efficiency of Bridging with Dabigatran Compared to Interruption of NOACs
Catheter ablation is an established method for treating supraventricular and ventricular arrhythmias. Patients with atrial fibrillation should also use anticoagulant therapy to prevent thromboembolic…
Prokinetics in the Treatment of Diabetic Gastroparesis
One of the common complications of diabetes mellitus is a motility disorder of the gastrointestinal tract, which can affect any part of the digestive tube, and therefore has various forms. Among…
Pregabalin can be chosen as the 1st line treatment for postherpetic neuralgia
The efficacy of pregabalin in patients with postherpetic neuralgia has been demonstrated in 4 multicenter randomized double-blind placebo-controlled studies.
Effect of Trifluridine/Tipiracil Combination Depending on Patient Prognosis
The results of the RECOURSE clinical study were published in 2015 and became an important basis for the approval of the trifluridine/tipiracil combination in the treatment of metastatic colorectal…
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