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Algorithm for Choosing Antidiabetics in Patients with Type 2 Diabetes

29. 7. 2020 Source: Diabetes

As of June 1, 2020, general practitioners can prescribe antidiabetics from the group of so-called gliptins, inhibitors of the enzyme dipeptidyl peptidase 4 (DPP-4i), in addition to metformin. The cornerstone of type 2 diabetes mellitus treatment remains a comprehensive lifestyle modification (dietary measures, increased physical activity, weight reduction) and metformin as the first-line drug. In selected comorbidities or if these measures do not lead to the desired glycated hemoglobin (HbA1c) level after 3-6 months, the following…

Major Orthopedic Procedures in Patients with Inhibitor Treated with Emicizumab

Italian authors presented the results of a study of a small series of hemophilia patients with inhibitors treated with emicizumab, who underwent major orthopedic surgery, at the World Federation of…

28. 7. 2020 Source: Quality Life Even with Hemophilia

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Comorbidities of Migraine and Their Impact on Pain Frequency and Intensity

The MAST study, published in March of this year in the prestigious The Journal of Headache and Pain, focused on the occurrence of associated diseases in patients with migraine. What is the prevalence…

27. 7. 2020 Source: Migraine

Starší doktor u počítače vysvětluje mladé pacientce její zdravotní stav.

What is the significance of hormones in the pathophysiology of migraine?

Migraine is a complex neurovascular disease characterized by the dysfunction of the nociceptive trigeminovascular system in its pathophysiology. Its prevalence is 2-3 times higher in women than in…

27. 7. 2020 Source: Migraine

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When to Initiate Dabigatran Therapy in Patients with Atrial Fibrillation After First Ischemic Stroke?

After a cardioembolic ischemic stroke (iCMP), approximately 5% of patients experience a recurrence within the first 14 days without anticoagulant therapy. The aim of the retrospective observational…

21. 7. 2020 Source: Anticoagulant Treatment

Insomnia a komorbidity

Trazodone as an Effective Medicine in the Therapy of Depression and Insomnia

Trazodone (Trittico®) is a medicine indicated for the treatment of depression, which has also been shown to have a positive effect in treating other associated conditions. In practice, however, the…

19. 7. 2020 Source: Depression and Anxiety

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Inflammation, Polyunsaturated Fatty Acids and Their Significance in the Development and Treatment of Depression

Depression is currently a highly discussed disease with a prevalence that is likely to rise. Therefore, scientists are focusing on potential causes and new treatment modalities. It has been shown…

19. 7. 2020 Source: Depression and Anxiety

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What Next for Patients with CLL After Stopping Venetoclax?

Standard care for untreated patients with chronic lymphocytic leukemia (CLL) is therapy based on venetoclax. However, managing further treatment when venetoclax needs to be discontinued remains a…

17. 7. 2020 Source: Chronic Lymphocytic Leukemia

Effect of Initiation of Warfarin Therapy on the Risk of Ischemic Stroke

Anticoagulant therapy is essential in patients with atrial fibrillation for the prevention of thromboembolic events. Warfarin is a highly effective anticoagulant, but the introduction of new oral…

17. 7. 2020 Source: Anticoagulant Treatment

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Current Indication Criteria for Testing Mutations in BRCA1 and BRCA2 Genes in Breast and Ovarian Cancer

Testing the mutation status of the BRCA1/2 genes can be beneficial for prevention, and in the case of already detected breast and/or ovarian cancer, also for direct treatment. We provide a brief…

16. 7. 2020 Source: Ovarian and Breast Cancer

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Aclidinium bromide improves the quality of life for COPD patients

The ON-AIR study conducted in real practice demonstrated the benefits of aclidinium bromide for the quality of life of patients with chronic obstructive pulmonary disease (COPD). It also assessed the…

15. 7. 2020 Source: Treatment of Asthma and COPD

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Study AMPLIFY Confirmed Safety and Efficacy of Fixed Combination Aclidinium/Formoterol in COPD Therapy

The randomized double-blind phase III AMPLIFY study compared the efficacy of a fixed combination of formoterol/aclidinium with monotherapy of the individual components or with tiotropium in patients…

15. 7. 2020 Source: Treatment of Asthma and COPD

Efficacy of L. reuteri DSM 17938 in Treating Acute Gastroenteritis in Children

Diarrheal diseases are among the most common causes of death worldwide in children under 5 years of age. Effective and timely treatment is crucial in the case of acute gastroenteritis (AGE), which is…

15. 7. 2020 Source: GI, colic and microbiome

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The Importance of Early Diagnosis and Treatment of AATD in Preventing Pulmonary Emphysema

Alpha-1 antitrypsin deficiency (AATD) is a risk factor for the development of various diseases, including pulmonary emphysema. Currently, it is significantly underdiagnosed, and the availability of…

13. 7. 2020 Source: Deficiency of Alpha-1-Antitrypsin

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Deficit Alpha-1-Antitrypsin as an Underestimated Problem? What a Survey Among European Experts Revealed

Alpha-1-antitrypsin deficiency (AATD) is a congenital disorder caused by mutations in the SERPINA1 gene. Although it is very well described, it is considered underdiagnosed and undertreated. A recent…

13. 7. 2020 Source: Deficiency of Alpha-1-Antitrypsin

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