Gender as a factor influencing clinico-pathological parameters and prognosis of renal cell carcinoma


Authors: V. Bartoš ;  R. Mráz ;  J. Mikuláš
Published in: Urol List 2013; 11(1): 0

Overview

Background:
Renal cell carcinoma (RCC) represents a heterogeneous group of oncological entities, that are characterized by some gender-related differences.

Aim:
The purpose of our paper was to evaluate the basic clinico-pathological parameters of the patients with RCC and to assess their gender-related disparities.

Material and methods:
A study group consisted of 172 bioptically verified cancers from 170 subjects (106 men, 64 women) in the age range between 18–90 years.

Results:
The mean age of the patients was almost the same for both sexes (men 63.0 years, women 62.3 years). A right kidney was more frequently affected in men (60.2%) and a left kidney in women (59.3%). Histologically, in both subgroups, clear cell type of RCC prevailed with approximately the same percentage (85.2 vs 84.4%). Papillary RCC occurred more commonly in men (12 vs 4.6%) and conversely, chromophobe RCC in women (6.2 vs 1.9%). Pathological stages confined to the kidney (pT1 and pT2) represented 64.8% and 76.6% in men and women, respectively. Stages with extrarenal propagation (pT3 and pT4) were found to be more common in men (35.2%) than women (23.4%). Compared to women, male gender exhibited larger cancers (mean size 4.9 vs 4.1 cm), more common multifocal lesions (13.9 vs 7.8%), more frequent metastatic involvement of the regional lymph nodes (9,2 vs 4,6%), as well as necrotic (43.5 vs 25%) and sarcomatoid changes (10.2 vs 7.8%) and their tumors tended to be poorely differentiated.

Conclusion:
Our study showed, that depending on gender, there were some differences in several clinico-pathological parameters of disease. Males more frequently exhibited unfavourable histomorphological findings, that probably correspond with their worse prognosis reported in the literature.

Key words:
renal cell carcinoma, gender, prognosis


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Paediatric urologist Urology

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