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Simultaneous ipsilateral native nephrectomy with kidney transplantation for the patiens with polycystic kidney disease


Authors: K. Morita;  T. Hirose;  H. Sasaki;  M. Masayoshi;  T. Tanabe;  D. Iwami;  K. Hotta;  N. Fukuzawa;  K. Nonomura
Published in: Urol List 2013; 11(1): 27-30

Overview

Prevention of perioperative complications related to an enlarged polycystic native kidney is mandatory when performing kidney transplantation for end-stage renal disease (ESRD) patients with polycystic kidney disease (PKD). The clinical course and outcome of kidney transplantation were retrospectively reviewed in ESRD patients with PKD. Eleven patients (6 males and 5 females; median age 54 years, age range 37–67 years at transplantation) were enrolled in this study. The median postoperative observation period was 35 (9–134) months. The native ipsilateral kidney was simultaneously removed with transplantation except for one case whose native kidney had been removed previously due to infection. All recipients are alive with functioning grafts. The median most recent serum creatinine level was 1.08 (0.67–3.17) mg/dl. Overall, 4 patients experienced acute rejection, 2 had viral infections, 2 had a bacterial native kidney infection (nephrectomized in 1), and 1 had ileus. Remaining kidney size was reduced in 6 patients, with no change in 4 and increased in only 1 patient who underwent native nephrectomy 11 years after transplantation. Native kidneys of PKD patients mostly reduce in size following successful kidney transplantation. Ipsilateral nephrectomy for the purpose of securing allograft space at transplantation is a safe and preferred procedure.

Key words:
complications, end-stage renal disease, kidney transplantation, native nephrectomy, polycystic kidney disease


Sources

1. Annual progress report from the Japanese renal transplant registry: Number of renal transplantation in 2010, part 2. The Japanese Society for Clinical Re­nal Transplantation. Ishoku 2011; 46(6): 506–523.

2. Kirkman MA, van Dellen D, Mehra S et al. Native nephrectomy for autosomal dominant polycystic kidney disease: before or after kidney transplantation? BJU Int 2011; 108(4): 590–594.

3. Charlson ME, Pompei P, Ales KL et al. A new me­thod of classifying prognostic comorbidity in longitu­dinal studies: Development and validation. J Chron Dis 1987; 40(5): 373–383.

4. Dindo D, Demartines N, Clavien P. Classification of surgical complications. A new proposal with evaluation in a cohort of 6,336 patients and results of a survey. Ann Surg 2004; 240(2): 205–213.

5. Desai MR, Nandkishore SK, Ganpule A et al. Pre­trans­plant laparoscopic nephrectomy in adult polycystic kidney disease: a single centre experience. BJU Int 2008; 101(1): 94–97.

6. Ekser B, Rigotti P. Autosomal dominant polycystic kidney disease. Images in clinical medicine. N Engl J Med 2010; 363(1): 71.

7. Cornelis F, Couzi L, Le Bras Y et al. Embolization of polycystic kidneys as an alternative to nephrectomy before renal transplantation: A pilot study. Am J Transpl 2010; 10(10): 2363–2369.

Labels
Paediatric urologist Urology

Article was published in

Urological Journal

Issue 1

2013 Issue 1

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