Sequencing of therapy and follow-up in patients with metastatic castrate resistant prostate cancer

Authors: J. Katolická
Published in: Urol List 2012; 10(4): 41-44


Two studies – TAX 327 and SWOG 9916 – have demonstrated for the first time the benefit in survival in patients with metastatic castrate resistant prostate cancer (mCRPC) treated with chemotherapy based on docetaxel, which is currently considered the standard agent for the first line treatment. III phase studies testing cabazitaxel, abirateron, sipuleucel-T, alpharadin, and enzalutamid as the second line treatment of castrate resistant prostate cancer have recently demonstrated benefit of prolonged survival while maintaining good quality of life and tolerable toxicity. More clinical studies and clinical experience are required to further reveal the correct sequencing of the individual agents.

Key words:
castrate resistant prostate cancer - docetaxel - cabazitaxel - abirateron - sipuleucel T - alpharadin - enzalutamid


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Paediatric urologist Urology
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