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Adverse events of hormone replacement testosterone therapy


Authors: J. Heráček;  V. Sobotka;  M. Urban;  R. Grill
Published in: Urol List 2012; 10(4): 12-14

Overview

Many signs of aging, such as sexual dysfunction, visceral obesity or reduction of bone and muscle strength, may be caused by hypogonadism. Correction of low levels of circulating androgens may improve aging symptoms. But as yet there is no definitive proof of long term safety of hormone replacement testosterone therapy to male body. On the contrary, there is evidence that testosterone is a main factor in the development of prostate cancer. The aim of the review article is to summarize adverse events of hormone replacement testosterone therapy in man treated for testosterone deficiency.

Key words:
hormone replacement therapy- testosterone - male - adverse event


Sources

1. Bhasin S, Cunningham GR, Hayes FJ et al. Testo­sterone therapy in adult men with androgen defi­ciency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2010; 95(6): 2536–2559.

2. Fernández-Balsells HM, Murad MH, Melanie L et al. Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. J Clin Endo­crinol Metab 2010; 95(6): 2560–2575.

3. Calof O, Singh AB, Lee ML et al. Adverse events associated with testosterone supplementation of older men. J Gerontol A Biol Sci Med Sci 2005; 60(11): 1451–1457.

4. Bachman E, Feng R, Travison T et al. Testosterone suppresses hepcidin in men: a potential mechanism for testosterone induced erythrocytosis. J Clin Endo­crinol Metab 2010; 95(10): 4743–4747.

5. Coviello AD, Kaplan B, Lakshman KM et al. Effects of graded doses of testosterone on erythropoesis in healthy young and older men. J Clin Endocrinol Metab 2008; 93(3): 914–919.

6. Matsumoto AM, Sandblom RE, Schoene RB et al. Testosterone replacement in hypogonadal men: effects on obstructive sleep apnoea, respiratory dri­ves, and sleep. Clin Endocrinol (Oxf) 1985; 22(6): 713–721.

7. Bhasin S. Regulation of body composition by androgens. J Endocrinol Invest 2003; 26(9): 814–822.

8. Barrett-Connor E, Khaw KT. Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study. Circulation 1988; 78(3): 539–545.

9. Carter HB. PSA variability versus velocity. Urology 1997; 49(2): 305.

10. Fowler JE Jr., Whitmore WF Jr. The response of metastatic adenocarcinoma of the prostate to exogenous testosterone. J Urol 1981; 126(3): 372–375.

Labels
Paediatric urologist Urology
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