On human ageing and longevity – 2. internal determinants

Authors: R. Brdička
Authors‘ workplace: Ústav hematologie a krevní transfuze a Ústav experimentální medicíny AV ČR, Praha
Published in: Čas. Lék. čes. 2009; 148: 330-334
Category: Special Articles


Longevity as a result of prolonged or postponed ageing is substantially influenced by genetic determinants. Most of them were analyzed by studying different progeria syndromes and their genetic control. From this point of view the use of experimental animals, because it enables to identify genes involved in shortening or prolongation of life-span by changing experimental conditions, has been also very effective. Expression of ageing processes at cellular as well on organism level as a biological unit revealed sets of genetic pathways involved in longevity. Several theories which elicit different aspects have been constructed to explain the ageing process.

Key words:
cell ageing, Hayflick limit, antagonistic pleiotrophy, progeria, lamins, cell cycle, DNA repair, RecQhelicases, sirtuins, telomeres, mitochondrion, hormones, sex differences, immunity.


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