Features of metabolic syndrome in patients with depressive disorder


Authors: M. Zeman 1;  R. Jirák 2;  A. Žák 1;  M. Jáchymová 1;  M. Vecka 1;  E. Tvrzická 1;  L. Vávrová 1;  J. Kodydková 1;  B. Staňková 1
Authors‘ workplace: Univerzita Karlova v Praze, 1. lékařská fakulta a VFN, IV. interní klinika 1;  Univerzita Karlova v Praze, 1. lékařská fakulta a VFN, Psychiatrická klinika, Centrum pro Alzheimerovu chorobu a Katedra psychiatrie IPVZ Praha 2
Published in: Čas. Lék. čes. 2009; 148: 309-314
Category: Original Article

Overview

Background.
Depressive disorder is a serious illness with a high incidence, proxime accessit after anxiety disorders among the psychiatric diseases. It is accompanied by an increased risk of development of type 2 diabetes mellitus, cardiovascular disease, and by increased all-cause mortality. Recently published data have suggested that factors connected with the insulin resistance are at the background of this association.

Methods and results.
In this pilot study we have investigated parameters of lipid metabolism and glucose homeostasis in consecutively admitted patients suffering from depressive disorder (DD) (group of 42 people), in 57 patients with the metabolic syndrome (MetS) and in a control group of 49 apparently healthy persons (CON). Depressive patients did not differ from the control group by age or body mass index (BMI) value, but they had statistically significantly higher concentrations of serum insulin, C-peptide, glucose, triglycerides (TG), conjugated dienes in LDL particles (CD-LDL), higher value of microalbuminuria and of insulin resistance (HOMA-IR) index. They simultaneously had significantly lower value of the insulin sensitivity (QUICKI) index. In comparison with the MetS group the depressive patients were characterized by significantly lower both systolic and diastolic blood pressure, BMI , serum TG, apolipoprotein B, uric acid, C-peptide and by higher concentrations of apolipoprotein A-I and HDL-cholesterol. On the contrary, we have not found statistically significant differences between the DD and MetS groups in the concentrations of serum insulin, glucose, HOMA and QUICKI indices, in CD-LDL and MAU.

Conclusions.
In this pilot study, we have found in patients with depressive disorder certain features of metabolic syndrome, especially insulin resistance and oxidative stress.

Key words:
depressive disorder, metabolic syndrome, insulin resistance, oxidative stress.


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