The Use of Lymphocytes and Cytogenetics Immunophenotypisation inEvaluation of Prognosis of Patients with B-chronic Lymphocytic Leukemia


Authors: E. Cmunt;  K. Michalová 1;  J. Karban;  Z. Zemanová 1;  L. Šindelářová 1;  Z. Bosáková 2;  J. Březinová 3;  Š. Kurková 3;  J. Schwarz 3
Authors‘ workplace: I. interní klinika 1. LF UK a VFN, Praha 1Centrum nádorové cytogenetiky 1. LF UK a VFN, Praha 2Ministerstvo práce a sociálních věcí ČR, Praha 3Ústav hematologie a krevní transfuze, Praha
Published in: Čas. Lék. čes. 2003; : 106-111
Category:

Overview

Background.
The B-chronic lymphocytic leukemia (B-CLL) has highly variable prognosis. Possibility of morerelevant prognosis has a great impact for the beginning and mode of therapy.Methods and Results. One hundred patients diagnosed as having B-CLL were included into the study. Beside usualexaminations necessary to establish the diagnosis, cytogenetic examination for the detection of deletion 13q14,17p13, 11q23 and trisomy 12 and immunophenotyping was done. The mean age of the patients was 58,2 years, therewere 62 men and 38 women. 91 evaluated patients were divided into two groups – those with the steady disease(55 pts) and those with progressive disease (36 pts). No relation between the number of cytogenetic abnormalitiesand the Rai stage of the disease was found. We identified a relation between the bone marrow infiltration pattern(diffuse) and the number of cytogenetic abnormalities and the del 13q14 (p.05). Using the immunophenotyping ofthe lymphocytes we found a relation between the expression of CD38 and CD11c and the disease progression(p

Key words:
Chronic lymphocytic leukemia B type (B-CLL), prognosis, fluorescence in situ hybridisation (FISH),imunofenotypisation.

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