Inflammatory Mechanisms in the Genesis and Progression of Atherosclerosis

Authors: A. Dvořáková;  R. Poledne
Authors‘ workplace: Centrum experimentálního výzkumu srdce a cév IKEM, Praha
Published in: Čas. Lék. čes. 2003; : 70-74


Recent studies have proved the importance of immune mechanisms participating in the genesis and progression ofatherosclerosis. This review depicts the role of macrophages and the mode of their activation, the part of cytokinesand T lymphocytes. Elevation of C-reactive protein and other acute phase reactants is a newly discovered characteristicof the atherosclerotic process, and their importance has been demonstrated in extensive epidemiologicaltrials. It is now recognized that subclinical inflammation (as a consequence of an activation of immune system) canbe caused by several factors: damage by acute inflammation, chronic infections, autoimmune damage (Hsp60).Genetic determination of the immune system reactivity has been intensively studied.

Key words:
atherosclerosis, inflammation, immune system, risk factors, infection, genetics.

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management
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