Pregestional diabetes mellitus and pregnancy

Authors: Jana Bělobrádková
Authors‘ workplace: Diabetologické centrum Interní gastroenterologické kliniky LF MU a FN Brno, pracoviště Bohunice
Published in: Vnitř Lék 2016; 62(Suppl 4): 26-29
Category: Reviews


There is a groving number of women with pregestational diabetes mellitus. Additionaly, nowadays therapy of diabetes mellitus type I allows gravidity even in patients in whom diabetes manifested itself during their early childhood. Presence of chronic complications of diabetes increases risk of complications during pregnancy. There is incerasing number of patients with DM type II and appearence of it shifts into younger age group. Perinatal mortality and morbidity of children of mothers with pregestional diabets is higher than in comparison with common population and pregnancy planning is important measure to their decrease.

Key words:
pregnancy – diabetes mellitus – embryopathy – fetopathy


1. Bartoš V, Pelikánová T. Praktická diabetologie. 5. ed. Maxdorf: Praha 2012. ISBN 978–80–7345–244–5.

2. Boluyt N, van Pempen A, Offringa M. Neurodevelopment after neonatal hypoglycemia: a systematic review and design of an optimal future study. Pediatrics 2006; 117(6): 2231–2242.

3. Briggs LE, Kakarla J, Wessels A. The pathogenesis of atrial and atrioventricular septal defects with special amphasis on the role dorsal mesenchymal protrusion. Differentation 2012; 84(1): 117–130. Dostupné z DOI: <>.

4. Coop AJ, Greene ND. Genetics and development of neural tube defects. J Pathol 2010; 220(2): 217–230. Dostupné z DOI: <>.

5. Coop AJ, Greene ND. Neural tube defects – disorders of neurulation and related embryonic processes. Wiley Interdiscip Rev Dev Biol 2013; 2(2): 213–227. Dostupné z DOI: <>.

6. Čechurová D, Andělová K. Doporučený postup péče o diabetes mellitus v těhotenství 2014. Standardy České diabetologické společnosti. Dostupné z WWW: Dostupné z DOI:

7. Hawdon J. The infant of a Diabetic mother. In: Roberton´s Textbook of Neonatology. 4th ed. Elsevier/Churchill Livingstone: 2005. ISBN 978–0443073557.

8. Klein BE, Moss SE, Klein R. Effects of pregnancyon progression of diabetic retinopathy. Diabetes Care 1990; 13(1): 34–40.

9. Kramer DC, Fleischer FS, Marx GF. Fetal bradycardia resulting from maternal hypoglycemia. A report of two cases. J Reprod Med 1995; 40(5): 394–396.

10. Merlob P, Levit O, Stahl B. Oral antihyperglycemic agents during pregnancy and lactation: a review. Paediatr Drugs 2002; 4(11): 755–760.

11. Miodovnik M, Minouni F, Dignan PS et al. Major malformations in infants of IDDM women. Vasculopathy and early first-trimester poor glycemic control. Diabetes Care 1988; 11(9): 713–718.

12. Neison SM, Freeman DJ, Sattar N et al. Erythrocytosis in off springs of mothers with Type 1 diabetes – are factors other than insulin critical determinants? Diabet Med 2009; 26(9): 887–892. Dostupné z DOI: <–5491.2009.02797.x>.

13. Reece EA, Coustan DR, Gabbe SG (eds). Diabetes in Women: Adolescence, Pregnancy and Menopause. 3rd ed. Lippincott Williams and Wilkins: Philadelphia 2004. ISBN 978–0781738613.

14. ter Braak EW, Evers IM, Willem Erkelens D et al. Maternal hypoglycemia during pregnancy in type 1 diabetes: maternal and fetal consequences. Diabetes Metab Res Rev 2002; 18(2): 96–105.

15. van Zalen-Sprock M, nav Vugt JM, van der Harten JJ et al. Early second-trimester diagnosis of sirenomelia. Prenat Diagn 1995; 15(2): 171–177.

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