Receptor pro konečné produkty pokročilé glykace (RAGE) – klíčový hráč diabetické angiopatie?


Authors: Jan Škrha Jr 1,2;  Marta Kalousová 2;  Tomáš Zima 2
Authors‘ workplace: III. interní klinika 1. LF UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA 1;  Ústav lékařské biochemie a laboratorní diagnostiky 1. LF UK a VFN Praha, přednosta prof. MUDr. Tomáš Zima, DrSc., MBA 2
Published in: Vnitř Lék 2014; 60(9): 782-786
Category:

Overview

Receptor for advanced glycation end-products plays a crucial role in chronic diabetes complications. It is supposed to be involved in the development of all kinds of diabetic angiopathy. Advanced glycation end-products (AGEs) excessively accumulated in diabetes belong to the most important ligands of RAGE, however there are more potent activators of this receptor – especially alarmins, often involved in inflammatory reactions. Activated RAGE triggers pathways leading to excessive accumulation of AGEs, reactive oxygen species and sustained inflammatory reactions via NF-κB. Central role of RAGE in the pathogenesis of vascular changes in diabetes represents suitable target for new therapeutic or preventive approach.

Key words:
advanced glycation end-products – diabetes mellitus – hyperglycaemia – macroangiopathy – methylglyoxal – microangiopathy – receptor for advanced glycation end-products


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Diabetology Endocrinology Internal medicine

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