Authors: Jindřich Olšovský Authors‘ workplace: II. interní klinika LF MU a FN u sv. Anny Brno, přednosta prof. MUDr. Miroslav Souček, CSc. Published in: Vnitř Lék 2014; 60(9): 737-740 Category:
In his paper, the author deals with hypoglycemia-related problems as the most frequent complication of the therapy for diabetes mellitus (DM). He points to threats that patients with hypoglycemia are exposed to, but also gives attention to risk groups of patients with regard to hypoglycemia development as well as different levels of the risk related to different antidiabetics.
Key words: antidiabetics – diabetes mellitus – hypoglycemia
1. UKPDS Group. U.K. Prospective Diabetes Study 16: Overview of 6 Years’ Therapy of Type II Diabetes: A Progressive Disease. Diabetes 1995; 44(11): 1249–1258.
2. Bonds DE, Miller ME, Bergenstal RM et al. The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ 2010; 340: b4909. Dostupné z DOI: <http://doi: 10.1136/bmj.b4909>.
3. Allen KV, Frier BM. Nocturnal hypoglycaemie: clinical manifestations and therapeutic strategie toward prevention. Endocr Pract 2003; 9(6): 530–543.
4. Donnelly LA, Morris AD, Frier BM et al. Frequency and predictors of hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes: a population-based study. Diabet Medicine 2005; 22(6): 749–755.
5. Chico A, Vidal-Ríos P, Subirà M et al. The continuous glucose monitoring system is useful for detecting unrecognized hypoglycemias in patients with type 1 and type 2 diabetes but is not better than frequent capillary glucose measurements for improving metabolic control. Diabetes Care 2003; 26(4): 1153–1157.
6. Weber KK, Lohmann T, Busch K et al. High frequency of unrecognized hypoglycaemias in patients with Type 2 diabetes is discovered by continuous glucose monitoring. Exp Clin Endocrinol Diabetes 2007; 115(8): 491–494.
7. DCCT Research Group. Epidemiology of severe hypoglycaemia in the diabetes control and complications trial. Am J Med 1991; 90(4): 450–459.
8. Graveling AJ, Frier BM. Impaired awareness of hypoglycaemie, a review. Diabetes Metab 2010; 36(Suppl 3): S64-S74.
9. Cryer PE. Exercise-related hypoglycemia-associated autonomic failure in diabetes. Diabetes 2009; 58(9): 1951–1952.
10. Desouza CV, Bolli GB, Fonseca V et al. Hypoglycemia, diabetes, and cardiovascular events. Diabetes Care 2010; 33(6): 1389–1394.
11. Laitinen T, Lyyra-Laitinen T, Huopio H et al. Electrocardiografic alterations during hyperinsulinemic hypoglycaemia in healty subjects. Ann Noninvasive Electrocardiol 2008; 13(2): 97–105.
12. Johnston SS, Conner C, Aagren M et al. Evidence linking hypoglycemic events to an increased risk of acute cardiovascular events in patients with type 2 diabetes. Diabetes Care 2011; 34(5): 1164–1170.
13. Phung OJ, Scholle JM, Talwar M et al. Effect of noninsulin antidiabetic drugh added to metformin therapy on glycemic control, weight gain and hypoglycaemia in type 2 diabetes. JAMA 2010; 303(14): 1410–1418.
14. Zammit NN, Frier BM. Hypoglycemia in type 2 diabetes: pathophysiology, frequency, and effects of different treatment modalities. Diabetes Care 2005; 28(12): 2948–2961.
15. Frier BM. How hypoglycaemia can affect the life of a person with diabetes. Diabetes Metab Res Rev 2008; 24(2): 87–92.
Don‘t have an account? Create new account
Enter the email address that you registered with. We will send you instructions on how to set a new password.
