Liver transplants in viral hepatitides

Czech version

Authors: L. Husová
Authors‘ workplace: Centrum kardiovaskulární a transplantační chirurgie Brno, ředitel doc. MU Dr. Petr Němec, CSc.
Published in: Vnitř Lék 2013; 59(8): 694-697
Category:

Overview

The authors present their own results of liver transplants over the last 30 years (from 2 February 1983 to 31 December 2012). For the respective period, 451 patients underwent a transplant in the Brno Transplantation Centre. Ten out of 451 patients (2.2%) underwent transplants for the indication of cirrhosis caused by viral hepatitis B in the Brno Transplantation Centre. The first liver transplant indicated due to viral hepatitis B was performed in 1994. Out of the ten patients, 3 died (30%). Forty‑ one out of 451 patients (9%) underwent liver transplant for cirrhosis caused by viral hepatitis C. The first liver transplant indicated due to viral hepatitis B was performed in 1991. A total of 21 patients out of 41 (51%) were treated with antiviral therapy; 27 out of 41 (66%) developed a recurrence after the liver transplant. Out of the 41 patients who underwent a liver transplant for viral hepatitis C indication, a total of 15 (36.6%) died.

Key words:
orthotopic liver transplantation – indication – cirrhosis – hepatitis B virus – hepatitis C virus

Sources

1. Šperl J. Transplantace jater pro virové hepatitidy. In: Trunečka P, Adamec M et al (eds). Transplantace jater. Praha: Karolinum 2009: 63– 74.

2. Killenberg PG, Clavin PA. Medical Care of the Liver Transplant Patient. New York: Blackwell Publishing 2006.

3. Francoz C, Belghiti J, Durand F. Indications of liver transplantation in patients with complications of cirrhosis. Best Pract Res Clin Gastroenterol 2007; 21: 175– 190.

4. Terrault N. Liver transplantation in the petting of chronic HCV. Best Pract Res Clin Gastroenterol 2012; 26: 531– 548.

5. Gane EJ, Patterson S, Strasser SI et al. Combination of lamivudine and adefovir without hepatitis B imine globulin is safe and effective prophylaxis against hepatitis B virus recurrence in hepatitis B surface antigen‑ positive liver transplant candidates. Liver Transpl 2013; 19: 268– 274.

6. Husa P. Trojkombinační léčba chronické hepatitidy C. Vnitř Lék 2012; 58: 588– 590.

7. Coilly A, Roche B, Samuel D. Current management and perspectives for HCV recurrence after liver transplantation. Liver Int 2012; 33 (Suppl 1):56– 62.

8. Coilly A, Roche B, Dumortier J et al. Efficacy and safety of protease inhibitors for severe Hepatitis C recurrence after liver transplantation: a first multicentric experience. J Hepatol 2012; 56 (Suppl 2): 21.