Myelodysplastic syndromes. Progress in diagnosis and treatment within 30 years of myelodysplastic syndromes registry in Institute of Hematology in Prague

Authors: J. Čermák
Authors‘ workplace: Ústav hematologie a krevní transfuze Praha, ředitel prof. MUDr. Marek Trněný, CSc.
Published in: Vnitř Lék 2012; 58(Suppl 2): 8-15


An analysis of data obtained from 367 patients with primary myelodysplastic syndromes (MDS) treated in Institute of Hematology and Blood Transfusion in the years 1980–2009 revealed substantional changes in diagnostic and therapeutic approaches within past 30 years. Molecular biology methods have been recently incorporated into the set of diagnostic methods and the importance of results obtained by molecular genetic methods for prognosis and optimal treatment is intensively studied. The treatment approaches switched from supportive care and palliative chemotherapy to new drugs that may effectively target the molecular basis of the disease as lenalidomide in early disease and hypomethylating agents in advanced MDS. Introduction of stem cell transplantation (SCT) significantly improved outcome especially in younger patients with advanced MDS and SCT still represents the only curative treatment approach.

Key words:
myelodysplastic syndromes – diagnosis – treatment – prognosis – registry


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