Chloroquine retinopathy: case report and recommendations for screening

Authors: B. Kousal;  Z. Dubská 1;  A. Beňová 1;  P. Diblík 1;  H. Langrová 1;  B. Kalvodová 2 1
Authors‘ workplace: Univerzita Karlova v Praze, 1. lékařská fakulta a Všeobecná fakultní nemocnice v Praze, Oční klinikaPřednostka: doc. MUDr. Bohdana Kalvodová, CSc. 1;  Univerzita Karlova v Praze, Lékařská fakulta v Hradci Králové, Oční klinikaPřednosta: prof. MUDr. Pavel Rozsíval, CSc., FEBO 2
Published in: Prakt. Lék. 2013; 93(4): 181-185
Category: Case Report


Long-term usage of the antimalarial drugs chloroquine and hydroxychloroquine has a retinotoxic effect. Toxicity is mainly dependent on the cumulative dose of medication and may persist even after treatment has been concluded. Eye examination comprising dilated fundus evaluation, testing the central 10 degrees of the visual field, spectral domain optical coherence tomography, fundus autofluorescence and multifocal electroretinography help with early detection of functional changes. Immediate discontinuation of these medications may reduce the risk of visual impairment. Regular ophthalmologic evaluation, interdisciplinary cooperation and patient education are important to prevent late ocular complications.

chloroquine – hydroxychloroquine – retinopathy – screening


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