Duplicitní malignita s paraneoplastickou polymyositidou
Kazuistika a přehled problematiky

Authors: V. Vomáčka;  A. Kreze jr.;  A. Zadražilová;  J. Koskuba;  M. Kosák
Authors‘ workplace: Fakultní nemocnice Na Bulovce, Praha ;  II. Interní oddělení ;  Primář: MUDr. Jiří Koskuba
Published in: Prakt. Lék. 2010; 90(9): 548-550
Category: Case Report


A case report of 50 year-old female suffering from muscle pains. Diagnosis of polymyositis was based on elevated muscle enzymes and electromyographic findings. Paraneoplastic origin was confirmed by findings: computer tomography for cancer of head and body of pancreas, and histology for stomach cancer. A concise review of paraneoplastic syndrome with emphasis on dermatomyositis/polymyositis syndrome is presented.

Key words:
carcinoma, paraneoplastic syndrome, polymyositis.


1. Baroni, A., Agozzino, M., Rossielo, L. Cutaneous paraneoplastic syndromes. G. Ital. Dermatol. Venerol. 2004, 139, p. 273-290.

2. Beukelaar, J.W., Sillevis, Smith. P.A. Managing paraneoplastic neurological disorders. Oncologist 2006, 11, p. 292-305.

3. Bohan, A., Peter, J.B. Polymyositis and dermatomyositis (second of two parts). NEJM 1975, 292, p. 403-407.

4. Darnell, R.B., Posner, J.B. Paraneoplastic syndromes involving the nervous system. NEJM 2003, 349, p. 1543-1154.

5. Hill, C.L., Zhang, Y., Sigurgeirsson, B. et al. Frequency of specific cancer types in dermatomyositis and polymyositis: a population based study. Lancet 2001, 357, p. 96-100.

6. Kim, M.J., Kim, J.A., Sung, M.S. et al. Hepatocelular carcinoma, polymyositis, rhabdomyolysis and acute renal failure. J. Korean. Med. Sci. 19, 2004, p. 981-894.

7. Koyama, S., Ikeda, K., Shibahara, K. et al. Transforming growh factor-alpha (THG-alpha)-producing gastric carcinoma with acanthosis nigricans: an endocrine effect of TGF-alpha in the pathogenesis of cutaneous paraneoplasic syndrome and epithelial hyperplasia of the esophagus. J. Gastroenterol. 1997, 32, p. 71-77.

8. Levine, S.M. Cancer and myositis: new insight into an old association. Curr. Opin. Rheumat. 2006, 18, p. 620-624.

9. O’Connel. M.J., Powel, T., Brennan, D. et al. Whole-body MR imaging in the diagnosis of polymyositis. AJR 179, 2002, p. 967-971.

10. Palma, G. Paraneoplastic syndromes of the nervous system. West. J. Med. 1985, 142, p. 787-796.

11. Ponyi. A., Constantin. T., Garami. M. et al. Cancer-associated myositis: Clinical features and prognostic signs. Ann. NY Acad. Sci. 1051, 2005, p. 64-71.

12. Rugo, H.S. The paraneoplastic syndromes. In: McPhee, SJ, Papadakis, MA, Tierney, ML Jr. Current medical diagnosis treatment. New York: Mc Graw Hill, 2007, p. 1728-1731.

13. Wagner, E. Falleiner selten Muskelkrankheit. DTSH Arch. Helik. 1863, 4, p. 282.

General practitioner for children and adolescents General practitioner for adults
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account