Quality of life improvement in patients with bone metastases treated by clodronate
Onkologické oddělení Fakultní Thomayerova nemocnice, Praha 4 — Krč
; Primář: prof. MUDr. Jitka Abrahámova, DrSc
Prakt. Lék. 2007; 87(11): 648-654
Bone metastases cause oncology patients a number of distressing problems. In addition to inducing risky episodes of hypercalceamia, they are the major cause of bone fractures, and contribute to the development of tumour pains in two-thirds of all patients, which greatly impacts upon their quality of life. Clodronate (BONEFOS®) is one of a number of bisphosphonates that has been used for the treatment of hypercalceamia and osteolysis arising from malignant tumours for the past 20 years.
the aim of the study was to verify the effect of clodronate treatment (1 600 mg/day perorally) on the quality of life and the subjective perception of state of health in Czech oncology patients using responses from EQ-5D (and particularly the VSA - visual analogue scale – level). 300 patients with either metastasised breast cancer or multiple myeloma were included in the study.
Clodronate treatment lasted for 9 months and yielded a significant improvement in overall patient mobility (p < 0.02) and the ability to carry out normal daily tasks (p < 0.001); it significantly reduced pains and/or other marked difficulties (p < 0.001) and also lowered the incidence of anxiety attacks or depression (p < 0.001), when compared with the state before treatment. Clodronate treatment was not shown to improve a patient’s ability to look after themselves (p = 0.19). Clodronate treatment did, however, significantly improve how patients subjectively perceived their health status on the VAS scale, when compared with the start of treatment (p < 0.001).
The study confirmed that clodronate (BONEFOS®) treatment considerably improves the subjective perception of state of health in oncology patients and significantly boosts their quality of life.
bone metastases, clodronate, quality of life.
General practitioner for children and adolescents
General practitioner for adults