Thyroid Peroxidase in Thyroid Gland Differential Diagnosis. The Marker ofMalignancy or Differentiation?

Authors: I. Kholová 1;  A. Ryška 1;  M. Ludvíková 3;  J. Čáp 2
Authors‘ workplace: Fingerlandův ústav patologie a 2II. interní klinika Lékařské fakulty Univerzity Karlovy a Fakultní nemocnice, Hradec Králové 3Šiklův patologicko-anatomický ústav Lékařské fakulty Univerzity Karlovy, Plzeň 1
Published in: Čes.-slov. Patol., , 2004, No. 1, p. 18-21


Human thyroid peroxidase (hTPO) is a membrane protein with a key role in the thyroid hormonessynthesis. Loss of hTPO was described in malignant tumours of the thyroid gland. hTPO wastested as a marker of malignancy. Immunohistochemical study of hTPO in 321 thyroid lesions (45malignant tumours, 72 benign tumours, 199 benign non-tumours lesions, and 5 normal thyroidglands) is presented. The sensitivity of hTPO in predicting malignancy in thyroid is 64 %, and thespecificity is 87 %. Thus, hTPO is of limited value in the diagnosis of thyroid malignancy. Theauthors discuss the role of hTPO as a marker of differentiation.

Key words:
human thyroperoxidase - thyroid gland - tumours - marker of malignancy - marker ofdifferentiation - immunohistochemistry

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