Authors: Š. Hadravská 1; A. Chlumská 2; L. Boudová 1; P. Mukenšnabl 1; M. Šulc 3 Authors‘ workplace: Department of Pathology, Medical Faculty Hospital, Plzeň, Czech Republic 2Surgical Pathology Laboratory, Plzeň, Czech Republic 3Surgical Pathology Laboratory, Chomutov, Czech Republic 1 Published in: Čes.-slov. Patol., , 2004, No. 1, p. 7-10 Category:
The development of the esophageal and gastric mucosa in the gastroesophageal junction wasstudied in 61 fetuses of 13 - 41 weeks of the gestational age. During the 13th - 15th week, theesophageal multilayered epithelium was covered by a continuous layer of columnar mucous ciliatedcells which were present only focally till the 25th week and disappeared later. Before the 15thweek, the gastric mucosa was formed by pits only. The glands started as proliferating tubules inthe basal parts of the pits in the 15th week. Further, they differentiated into oxyntic glands. Themucosa of the corpus was fully developed in the 27th week. The cardiac mucosa was absent in allthe 10 fetuses examined between the 27th and 41st week of gestation. This supports the view thatthe gastric cardiac mucosa is not a physiological structure but that it results from glandularmetaplasia of the distal esophageal mucosa due to gastroesophageal reflux.
Key words: development of esophagus and stomach - cardia - gastroesophageal reflux - glandularmetaplasia of the esophageal mucosa
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