Authors: E. Honsová 1; A. Lodererová 1; T. Havrdová 2; L. Voska 1; P. Bouček 2 Authors‘ workplace: Pracoviště klinické a transplantační patologie, IKEM, Praha 2Klinika diabetologie, Centrum diabetologie, IKEM, Praha 1 Published in: Čes.-slov. Patol., , 2004, No. 1, p. 25-28 Category:
BK-virus nephropathy was recently recognised as a new complication that affects renal allograftsand causes dysfunction. We report a case of a recipient of simultaneous kidney-pancreas allografts.Fourteen months after the transplant, the renal allograft became dysfunctional with elevationof serum creatinine level. The diagnosis of BK-virus nephropathy was established by needlerenal biopsy with immunohistochemical detection of human polyoma virus. Immunosuppressivetherapy was reduced but progressive dysfunction developed and the patient had to undergoa renal retransplantation 11 months after the diagnosis of the infection. Due to repeated renaldysfunction, needle biopsy was performed, and the diagnosis of repeated BK-virus nephropathywas established six months after the retransplantation. The pancreas allograft has functionedwell for the entire period.
Key words: BK virus - BK virus nephropathy - immunohistochemical detection of polyomavirus -transplantation
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