Plexiform Fibrohistiocytic Tumor of Soft Tissues and Bone

Authors: C. Povýšil;  B. Habanec
Authors‘ workplace: II. patologickoanatomický ústav 1. LF UK a VFN, katedra patologické anatomie
Published in: Čes.-slov. Patol., , 2000, No. 3, p. 106-110


Plexiform fibrohistiocytic tumor is a rare lesion which has been reported only in the dermis andsubcutis so far. We present two cases in this location and an additional one localized in theproximal epiphysis of the tibia. A case with crural location showed predominance of plexiformtumorous nodes with fibrohistiocytic arrangement. The nodes were composed of spindle-shapedmyofibroblasts with admixture of histiocytes and giant multinucleated osteoclast-like cells. Inanother case the tumor of axillary soft tissues featured mostly plexiform bundles of spindle-sha-ped myofibroblast-like cells reacting positively with actin and CD 68 antibodies; ultrastructurally,they contained numerous dense lysosomal inclusions with myelin figures. The bone tumor wascomposed of hyalinized fibroblastic component with disperse fibrohistiocytic nodes. Despite a se-mimalignant character of the lesion there was no recurrence in our cases during the 2 - 6 yearpostoperative period.

Key words:
plexiform fibrohistiocytic tumor - soft tissues - bone – immunohistochemistry - elec-

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