Some Biological Characteristics in Multiple Myeloma
J. †dušek 1; V. Ščudla 2; Z. Kolář 1,3; P. Řiháková 1,3; A. Hlobilová 1,3
Ústav patologie, Olomouc
Čes.-slov. Patol., , 2000, No. 3, p. 111-115
On a series of thirty trephine bone marrow biopsies from patients with multiple myeloma, theauthors evaluated expression of markers of cell proliferation or of its blockade (Ki-67, PCNA,topoisomerase IIa, cyclin D-1, AgNOR, and p27 kip1 ) and markers indicating multidrug resistance(P-170 and Bcl-2). Expression of Ki-67 and of topoisomerase IIa was unfrequent. Marked positivityof PCNA was expressed in about one third of cases, negative staining was exceptional. No expres-sion of cyclin D-1 was noted. Positivity of p27 kip1 was frequent. P-170 was demonstrated in a smallnumber of cases, Bcl-2 was strongly positive in most cases. The results characterise multiplemyeloma as a tumour with low proliferation rate and, simultaneously, with high resistance toapoptosis.
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