Intestinal T-cell Lymphoma

Authors: F. Fakan;  L. Plank *;  P. Szépe *;  L. Boudová;  V. Feit **;  S. Náměstek ***
Authors‘ workplace: Šiklův patologicko-anatomický ústav LF Univerzity Karlovy a FN, Plzeň
Published in: Čes.-slov. Patol., , 2000, No. 3, p. 94-98


In our study, 7 bioptical specimens of intestinal T-cell lymphoma are described. This tumouroccurs in the small intestine of adults who may have a history of malabsorption. The patientspresent clinically with intestinal perforation, enterorrhagia, or ileus. The gross appearance vari-es: the tumour may take the form of multiple ulcers or of a huge exulcerated lesion. The cytomor-phological features are variable. Bizarre multinucleated cells may be sometimes present. Thereactive cellular background is usually dominated by histiocytes or eosinophilic granulocytes.Immunohistochemically, the tumour cells stain in reactions with antibodies to pan T-cell mar-kers, occasionally to CD8 and CD30. The positivity of tumour cells for markers of intraepithelialT-cells and for cytotoxic molecules has been demonstrated previously.

Key words:
intestinal T-cell lymphoma - histomorphology - immunohistochemistry - differential

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