Postinitial remission in children with type 1 diabetes mellitus

Czech version

Authors: Podoláková Kristína ¹; Lobotková Denisa ¹; Jančová Emília ¹; Podracká Udmila ¹; Barák Ubomír ¹; Staník Juraj ^1,2
Authors‘ workplace: Detská klinika, Lekárska fakulta, Univerzity Komenského, a Národný ústav detských, chorôb, Bratislava ¹; DIABGENE a Oddelenie, výskumu porúch, metabolizmu, Ústav experimentálnej, endokrinológie, Biomedicínske centrum, Slovenskej Akadémie vied, Bratislava ²
Published in: Čes-slov Pediat 2022; 77 (2): 72-77.
Category: Comprehensive Report

Overview

Post-initial remission is a period that occurs shortly after the initiation of treatment for type 1 diabetes mellitus (T1D) and is characterized by a transient improvement in residual endogenous insulin secretion accompanied by a reduced need for exogenous insulin and good glycemic control. Remission occurs in more than ⅓ of children with newly diagnosed T1D, and most cases are partial remission with a reduction in daily insulin dose < 0.5 IU/kg/day; complete remission with temporary discontinuation of insulin therapy is rare. Several factors influence the development and length of remission - known factors include age and early diagnosis of T1D, when diabetic ketoacidosis is not yet developed and the residual secretory capacity of the remaining β-cells secreting insulin is better. In our review article, we discuss in more detail the factors influencing remission as well as efforts to influence the development and duration of post-initial remission pharmacologically or with new technologies.

Keywords:

remission – type 1 diabetes mellitus – children – T1D – factors

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