COVID-19 pandemic of the pediatric population in the Ústí nad Labem region
Authors:
Vičar Josef 1; Patrasová Eva 2; Balatka Vojtěch 1
Authors‘ workplace:
Dětská klinika Fakulty zdravotnických studií Univerzity J. E. Purkyně v Ústí nad Labem a Krajské zdravotní, a. s. – Masarykova nemocnice v Ústí nad Labem, o. z.
1; Protiepidemický odbor, Krajská hygienická stanice Ústeckého kraje
2
Published in:
Čes-slov Pediat 2022; 77 (2): 103-114.
Category:
Original Papers
Overview
Objective: To describe the severity of COVID-19 (coronavirus disease 2019) infections within the cohort of all infected children registered in the Ústí region from the pandemic origin until the 31th March 2021.
Methods: A retrospective study based on data obtained from the Public Health Office of the Ústí nad Labem region, the National Information System of infectious diseases and hospitals in the Ústí nad Labem region.
Results: By 31 March 2021, 15,395 cases of covid-19 aged 0-18 were registered in the Ústí region, which made up 14% of all infected patients. A total of 5650 children were asymptomatic (36,7 %), most commonly in an age range of 0-9 years (46,0 %). The remaining patients had mild symptoms and only 75 children were admitted to for hospital care. Three children died of respiratory failure, all of which had severe comorbidities. Three children were diagnosed with Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 (PIMS-TS). The proportion of asymptomatic children decreased during the months of alpha mutation spreading, however this did not affect the number of hospitalized patients.
Conclusion: Severe cases of COVID-19 occurring in children were rare events during the study period. A total of 75 children (0,49 %) were admitted for hospital care due to COVID-19 infections. Nine children were in severe clinical conditions, of which seven had major comorbidities and three died.
Keywords:
hospitalization – mortality – COVID-19 – pneumonia – children
Sources
1. Stokes EK, Zambrano LD, Anderson KN, et al. Coronavirus Disease 2019 Case Surveillance – United States, January 22- May 30, 2020. Morbidity Mortality Weekly Report (MMWR) 2020; 69(24): 759–765.
2. Dong Y, Mo X, Hu Y, et al. Epidemiology of COVID-19 among children in China. Pediatrics 2020; 145(6): e20200702.
3. Hobbs CV, Martin LM, Kim SS, et al.; CDC COVID-19 Response Team. Factors associated with positive SARS-CoV-2 test results in outpatient health facilities and emergency departments among children and adolescents aged < 18 years - Mississippi, September-November 2020. Morbidity Mortality Weekly Report MMWR 2020; 69(50): 1925–1929.
4. Pollán M, Pérez-Gómez B, Pastor-Barriuso R, et al. Prevalence of SARSCoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. Lancet 2020. doi: 10.1016/ S0140-6736(20)31483-5
5. Oran DP, Topol EJ. The proportion of SARS-CoV-2 infections that are asymptomatic: a systematic review. Ann Intern Med 2021; 174(5): 655–662.
6. Götzinger F, Santiago-García B, Noguera-Julián A, et al.; COVID-19 Study Group. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health 2020; 4(9): 653–661.
7. Beck A, Gandhi M. Adjudicating reasons for hospitalization shows that severe illness from COVID-19 in children is rare. Hospital Pediatr 2021; 19:e2021006084. doi: 10.1542/ hpeds.2021-006084
8. Kushner LE, Schroeder AR, Kim J, Mathew R. “For COVID” or “with COVID”: classification of SARS-CoV-2 hospitalizations in children. Hospital Pediatr 2021; e2021006001. doi: 10.1542/hpeds.2021-006001
9. Ouldali N, Pouletty M, Mariani P, et al. Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis. Lancet Child Adolesc Health. doi: 10.1016/S2352- 4642(20)30175-9
10. Davies P, Evans C, Kanthimathinathan HK, et al. Intensive care admissions of children with paediatricinflammatory multisystem syndrome temporally associated with SARS- -CoV-2 (PIMS-TS) in the UK: a multicentre observational study. Lancet Child Adolesc Health 2020. doi: 10.1016/ S2352-4642(20)30215-7
11. Verdoni L, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet 2020. doi: 10.1016/ S0140-6736(20)31103-X
12. Felstein LR, et al. Multisystem Inflammatory Syndrome in U.S. children and adolescents. NEJM 2020. doi: 10.1056/ NEJMoa2021680
13. Fencl F, Šibíková M, David J, Malcová H. Syndrom multisystémové zánětlivé odpovědi asociovaný s COVID-19 u dětí. Doporučený postup ČPS ČLS JEP. Čes-slov Pediatrie 2021; 76(1): 4–9.
14. Brookman S, Cook J, Zucherman M, et al. Effect of the new SARS-CoV-2 variant B.1.1.7 on children and young people. Lancet Child Adolesc Health 2021. doi: 10.1016/S2352- 4642(21)00030-4
15. European Centre for Disease Prevention and Control. COVID- 19 situation update worldwide, as of week 11, updated 25 March 2021. Stockholm: ECDC 2021. Dostupné na: https:// www.ecdc.europa.eu/en/geographical-distribution- -2019-ncov-cases
16. Guidance: Paediatric multisystem inflammatory syndrome temporally associated with COVID19, Royal College of Paediatrics and Child Health. Dostupné na: https:// www.rcpch.ac.uk/sites/default/files/2020-05/COVID-19-Paediatric-multisystem- %20inflammatory%20syndrome- 20200501.pdf
17. Dufort EM, Koumans EH, Chow EJ, et al.; New York State and Centers for Disease Control and Prevention Multisystem Inflammatory Syndrome in Children Investigation Team. Multisystem Inflammatory Syndrome in children in New York State. N Engl J Med 2020; 383(4): 347– 358.
18. Lu X, Zhang L, Du H, et al.; Chinese Pediatric Novel Coronavirus Study Team. SARS-CoV-2 infection in children. N Engl J Med 2020; 382(17): 1663–1665.
19. Wei M, Yuan J, Liu Y, et al. Novel coronavirus infection in hospitalized infants under 1 year of age in China. JAMA 2020; 323(13): 1313–1314.
20. Zimmermann P, Curtis N. Coronavirus infections in children including COVID-19: An overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. Pediatr Infect Dis J 2020; 39(5): 355–368.
21. Rosenberg ES, Dufort EM, Blog DS, et al.; New York State Coronavirus 2019 Response Team. COVID-19 testing, epidemic features, hospital outcomes, and household prevalence, New York State—March 2020. Clin Infect Dis 2020. doi: 10.1093/cid/ciaa549
22. CDC COVID-19 Response Team. Coronavirus Disease 2019 in children - United States, February 12-April 2, 2020. Morbidity Mortality Weekly Report MMWR. 2020; 69(14): 422– 426.
23. Jiřincová H, Nagy A. Surveillance variant/mutací SARS- -CoV-2 v ČR, prezentace NRL pro ECDC, 6. březen 2021. Dostupné na: http://www.szu.cz/tema/prevence/surveillance- variant-mutaci-sars-cov-2-v-cr
24. Kelvin AA, Halperin S. COVID-19 in children: the link in the transmission chain. Lancet Infect Dis 2020; 20(6): 633–634.
25. Huff HV, Singh A. asymptomatic transmission during the coronavirus disease 2019 pandemic and implications for public health strategies. Clin Infect Dis 2020; 71(10): 2752– 2756.
26. Soriano-Arandes A, Gatell A, Serrano P, et al.; COPEDI-CAT research group. Household SARS-CoV-2 transmission and children: a network prospective study. Clin Infect Dis 2021. doi: 10.1093/cid/ciab228
27. Grijalva CG, Rolfes MA, Zhu Y, et al. Transmission of SARS- -COV-2 infections in households - Tennessee and Wisconsin, April-September 2020. Morbidity Mortality Weekly Report MMWR 2020; 69(44): 1631–1634.
28. Park YJ, Choe YJ, Park O, et al.; COVID-19 National Emergency Response Center, Epidemiology and Case Management Team. Contact tracing during coronavirus disease outbreak, South Korea, 2020. Emerg Infect Dis 2020; 26(10): 2465–2468.
29. Posfay-Barbe KM, Wagner N, Gauthey M, et al. COVID-19 in children and the dynamics of infection in families. Pediatrics 2020; 146(2): e20201576. doi: 10.1542/peds.2020- 1576
30. Zachariah P, Johnson CL, Halabi KC, et al.; Columbia Pediatric COVID-19 Management Group. Epidemiology, clinical features, and disease severity in patients with coronavirus disease 2019 (COVID-19) in a Children’s Hospital in New York City, New York. JAMA Pediatr 2020; 174(10): e202430. doi: 10.1001/jamapediatrics.2020.2430
31. Hoang A, Chorath K, Moreira A, et al. COVID-19 in 7780 pediatric patients: A systematic review. EClinical- Medicine. 2020 Jun 26; 24: 100433. doi: 10.1016/j.eclinm. 2020.100433.
32. Chua GT, Wong JSC, Lam I, et al. Clinical characteristics and transmission of COVID-19 in children and youths during 3 waves of outbreaks in Hong Kong. JAMA Netw Open 2021; 4(5): e218824. doi: 10.1001/jamanetworkopen.2021. 8824
33. European Centre for Disease Prevention and Control. COVID- 19 in children and the role of school settings in transmission – second update. 8 July 2021. Stockholm: ECDC 2021. Dostupné na: https://www.ecdc.europa.eu/sites/default/ files/documents/COVID-19-in-children-and-the-role-of- -school-settings-in-transmission-second-update.pdf
34. Macartney K, Quinn HE, Pillsbury AJ, et al.; NSW COVID- 19 Schools Study Team. Transmission of SARS-CoV-2 in Australian educational settings: a prospective cohort study. Lancet Child Adolesc Health 2020; 4(11): 807– 816.
35. Parri N, Lenge M, Buonsenso D; Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) Research Group. Children with Covid-19 in pediatric emergency departments in Italy. N Engl J Med. doi: 10.1056/ NEJMc2007617
36. Yonker LM, Neilan AM, Bartsch Y, et al. Pediatric SARS- -CoV-2: Clinical presentation, infectivity, and immune responses. J Pediatr 2020. doi: 10.1016/j.jpeds.2020.08.037
37. Webb NE, Osburn TS. Characteristics of hospitalized children positive for SARS-CoV-2: Experience of a large center. Hosp Pediatr 2021: e2021005919. doi: 10.1542/ hpeds.2021-005919
38. Kushner LE, Schroeder AR, Kim J, Mathew R. “For COVID” or “with COVID”: classification of SARS-CoV-2 hospitalizations in children. Hospital Pediatr 2021; e2021006001. doi: 10.1542/hpeds.2021-006001
39. American Academy of Pediatrics, Children and COVID-19: State-Level Data Report. Dostupné na: https://services. aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/ children-and-covid-19-state-level-data-report/
40. Shekerdemian LS, Mahmood NR, Wolfe KK, et al.; International COVID-19 PICU Collaborative. Characteristics and outcomes of children with coronavirus disease 2019 (COVID-19) infection admitted to US and Canadian Pediatric Intensive Care Units. JAMA Pediatr 2020; 174(9): 868–873.
41. Irfan O, Muttalib F, Tang K, et al. Clinical characteristics, treatment and outcomes of paediatric COVID-19: a systematic review and meta-analysis. Arch Dis Child 2021; 106(5): 440–8.
42. Kim L, Whitaker M, O’Halloran A, et al.; COVID-NET Surveillance Team. Hospitalization rates and characteristics of children aged <18 years hospitalized with laboratory-confirmed COVID-19 - COVID-NET, 14 States, March 1-July 25, 2020. Morbidity Mortality Weekly Report MMWR 2020; 69(32): 1081–1088.
43. Newman AM, Jhaveri R, Patel AB, et al. Trisomy 21 and coronavirus disease 2019 in pediatric patients. J Pediatr 2021; 228: 294–296. doi: 10.1016/j.jpeds.2020.08.067
44. Dufort EM, Koumans EH, Chow EJ, et al.; New York State and Centers for Disease Control and Prevention Multisystem Inflammatory Syndrome in Children Investigation Team. Multisystem Inflammatory Syndrome in children in New York State. N Engl J Med 2020; 383(4): 347–358.
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Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
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