Rotaviruses and other agents causing gastroenteritis in patients hospitalized at the Department of Pediatric Infectious Diseases, University Hospital, Brno, in 2015–2016
Authors:
M. Malá 1; M. Trnková 1; V. Musil 1; A. Ševčíková 2; L. Krbková 1
Authors‘ workplace:
Klinika dětských infekčních nemocí LF MU a FN Brno
1; Oddělení klinické mikrobiologie, FN Brno
2
Published in:
Čes-slov Pediat 2017; 72 (7): 396-403.
Category:
Overview
Objective:
To analyze the etiology of intestinal pathogens in children hospitalised at the Department of Pediatric Infectious Diseases, University Hospital, Brno, in 2015–2016 with a focus on rotavirus gastroenteritis (RVGE).
Methods:
A retrospective study evaluates pediatric patients aged 0–18 with symptoms of gastroenteritis hospitalized from January 1, 2015 to December 31, 2016. Rectal swabs for cultivation of the intestinal pathogens were collected from all patients and, in some cases, the stool samples for the identification of viral antigens and for the detection of Clostridium difficile.
Results:
Patients with gastroenteritis were hospitalized in a total of 1083 in 2015 and 988 in 2016. We proved a viral infection at 36.0% and 29,0% in 2015 and 2016, respectively. RVGE were confirmed in 28.2% and 18.2%, adenovirus gastroenteritis in 3.2% and 5.0%, norovirus gastroenteritis in 4.6% and 5.8%. Both years bacterial infections were confirmed in 14.6% of patients, most of them salmonellosis (9.3%, 8.3%), less campylobacteriosis (4.2%, 5.2%), the clostridial colitis (0.9%, 0.7%) and the least of all yersinioses (0.0%, 0.4%). No one was hospitalized with an infection caused by Shigella spp. Etiology remained unclear in 49.7% and 56.6% cases in 2015 and 2016, respectively. Maximum cases of viral diseases occurred in children under 5 years of age (83.3%, 82.5%), specifically in the age group 13–36 months (44.6%, 47.6%). The highest number of cases in patients with RVGE were also in children under 5 years of age (82.3%, 80.6%) and 13–36 months (41.0%, 42.8%). Maximum cases of bacterial diseases occured in children over 5 years of age (54.4%, 46.5%). Most RVGE were registered in April 2015 and in March and April 2016.
Conclusion:
Patients with RVGE, even at a time of available vaccination, form a significant proportion of patients treated for gastroenteritis (23.4%).
Keywords:
acute gastroenteritis, rotavirus, rotavirus gastroenteritis, children
Sources
1. Krbková L, Mikolášek P, Musil V. Terapie průjmových onemocnění dětí (aneb co se změnilo v průběhu 70 let). Čes-slov Pediat 2016; 71 (3): 150–155.
2. Esona MD, Gautam R. Rotavirus. Clin Lab Med 2015; 35 (2): 363–391.
3. O’Ryan M. The ever-changing landscape of rotavirus serotypes. Pediatr Infect Dis J 2009; 28 (3 Suppl): S60–62.
4. Bernstein DI. Rotavirus overview. Pediatr Infect Dis J 2009; 28 (3 Suppl): S50–53.
5. Moutelíková R, Prodělalová J. Možnosti zoonotického přenosu rotavirových infekcí. Epidemiol Mikrobiol Imunol 2015; 64 (2): 66–71.
6. Hyser JM, Estes MK. Rotavirus vaccines and pathogenesis: 2008. Curr Opin Gastroenterol 2009; 25 (1): 36–43.
7. Vesikari T, Sarkkinen HK, Mäki M. Quantitative aspects of rotavirus excretion in childhood diarrhoea. Acta Paediatr Scand 1981; 70 (5): 717–721.
8. Ray PG, Kelkar SD, Walimbe AM, et al. Rotavirus immunoglobulin levels among Indian mothers of two socio-economic groups and occurrence of rotavirus infections among their infants up to six months. J Med Virol 2007; 79 (3): 341–349.
9. Beneš J, Husa P, Nyč O, et al. Doporučený postup diagnostiky a léčby kolitidy vyvolané Clostridium difficile. Klin Mikrobiol Inf Lék 2014; 20 (2): 56–66.
10. Parashar UD, Hummelman EG, Bresee JS, et al. Global illness and deaths caused by rotavirus disease in children. Emerg Infect Dis 2003; 9 (5): 565–572.
11. Tate JE, Burton AH, Boschi-Pinto C, et al. 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis 2012; 12 (2): 136–141.
12. Soriano-Gabarró M, Mrukowicz J, Vesikari T, et al. Burden of rotavirus disease in European Union countries. Pediatr Infect Dis J 2006; 25 (1 Suppl): S7–11.
13. Tichopád A, Müllerová J, Jackowska T, et al. Cost burden of severe community-acquired rotavirus gastroenteritis requiring hospitalization in the Czech Republic, Slovakia, Poland, and Hungary: A retrospective patient chart review. Value Health Reg Issues 2016; 10: 53–60.
14. Pazdiora P, Beneš Č. Rotavirus gastroenteritis in the Czech Republic before the start of vaccination. Epidemiol Mikrobiol Imunol 2013; 62 (4):131–137.
15. Fajfr M, Stěpánová V, Plíšková L, et al. Viral gastroenteritis in Eastern Bohemia Region of the Czech Republic. Epidemiol Mikrobiol Imunol 2014; 63 (2): 88–91.
16. Mészner Z, Anca I, André F, et al. Rotavirus vaccination in central Europe. J Pediatr Gastroenterol Nutr 2013; 56 (6): 586–596.
17. Forster J, Guarino A, Parez N, et al. Hospital-based surveillance to estimate the burden of rotavirus gastroenteritis among European children younger than 5 years of age. Pediatrics 2009; 123 (3): e393-400.
18. Dóró R, László B, Martella V, et al. Review of global rotavirus strain prevalence data from six years post vaccine licensure surveillance: is there evidence of strain selection from vaccine pressure? Infect Genet Evol 2014; 28: 446–461.
19. Diez-Domingo J, Baldo J-M, Patrzalek M, et al. Primary care-based surveillance to estimate the burden of rotavirus gastroenteritis among children aged less than 5 years in six European countries. Eur J Pediatr 2011; 170 (2): 213–222.
20. Karafillakis E, Hassounah S, Atchison C. Effectiveness and impact of rotavirus vaccines in Europe, 2006-2014. Vaccine 2015; 33 (18): 2097–2107.
21. Hungerford D, Smith K, Tucker A, et al. Population effectiveness of the pentavalent and monovalent rotavirus vaccines: a systematic review and meta-analysis of observational studies. BMC Infect Dis 2017; 17 (1): 569.
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Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2017 Issue 7
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