Deep venous thrombosis in a child with nephrotic syndrome – case report
Authors:
Ľ. Kováčiková ml. 1; M. Chocholová 1; M. Ondriska 2; Ľ. Podracká 1
Authors‘ workplace:
1. detská klinika LFUK a DFNsP, Bratislava
prednostka prof. MUDr. Ľ. Podracká, CSc.
1; Rádiologické oddelenie DFNsP, Bratislava
vedúci prim. MUDr. D. Haviar
2
Published in:
Čes-slov Pediat 2016; 71 (2): 91-95.
Category:
Case Report
Overview
Deep venous thrombosis in a child with nephrotic syndrome – case report
In children with nephrotic syndrome thrombosis is well known and formidable complication with incidence of 2 to 9%. Nephrotic syndrome is associated with acquired hypercoagulation status. Etiology is multifactorial. Thrombogenic milieu is a result of urinary loss (antithrombin III, protein S) and increased synthesis of procoagulation factors (fibrinogen, V and VIII factors). Impaired fibrinolysis, hemoconcentration, patient immobility especially in association with anasarca, infection and central venous catheter are further contributing factors. Deep venous thrombosis can occur at venous or arterial system, most frequently in lower limb deep veins, renal veins, pulmonary circulation. Less frequently, thrombosis is located in other areas of vascular system. Anticoagulation therapy is indicated according to severity of thrombotic complication. Prophylaxis is recommended only in children with high risk for thrombosis.
Authors present a rare case of familiar, primary corticoresistant nephrotic syndrome complicated with extensive deep venous thrombosis in an toddler.
Key words:
nephrotic syndrome in children, deep venous thrombosis, anticoagulation therapy
Sources
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Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2016 Issue 2
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