Shiga toxin-producing Escherichia coli infections in children


Authors: L. Karnišová 1;  F. Fencl 1;  M. Marejková 2;  M. Malina 1;  J. Zieg 1;  K. Bláhová 1
Authors‘ workplace: Pediatrická klinika 2. LF UK a FN Motol, Praha přednosta prof. MUDr. J. Lebl, CSc. 1;  Národní referenční laboratoř pro E. coli a shigely, Státní zdravotní ústav, Praha vedoucí ing. M. Marejková, Ph. D. 2
Published in: Čes-slov Pediat 2016; 71 (2): 98-103.
Category: Review

Overview

Shiga toxin-producing Escherichia coli (STEC) are an important cause of diarrhea and the major cause of typical form of hemolytic-uremic syndrome (HUS) worldwide. Manifestation of STEC infection can be diverse, from uncomplicated diarrhea through hemorrhagic colitis, to a serious systemic disease – HUS, that is the most common cause of acute kidney injury, especially in young children.

Due to possible progression of diarrhea to life-threatening illness, all physicians treating patients with diarrhea should get familiar with the epidemiology, pathogenesis and clinical symptomes of infection caused by the organism.

This article describes the history, epidemiology, pathogenesis, clinical aspects, and diagnostic methods of STEC infections.

Key words:
Shiga toxin-producing E. coli (STEC), hemolytic-uremic syndrome (HUS), STEC-HUS/typical HUS/classical form of HUS/diarrhea positive HUS/D+HUS, diagnosis, epidemiology, clinical symptoms


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Labels
Neonatology Paediatrics General practitioner for children and adolescents
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