Antiendomysial Antibodies as Serological Screening of Coeliac Disease

Authors: M. Krajčírová 1;  I. Čierna 1;  E. Tibenská 2;  M. Zaviačič 3
Authors‘ workplace: II. detská klinika DFNsP, Bratislava, 1prednostka prof. MUDr. A. Kapellerová, DrSc. Oddelenie klinickej imunológie DFNsP, Bratislava, 2primár MUDr. M. Jančár, CSc. Katedra patologickej anatómie LFUK, Bratislava, 3prednosta prof. MUDr. M. Zaviačič, DrSc.
Published in: Čes-slov Pediat 1999; (11): 670-672.


Coeliac disease is a lifelong condition with different clinical manifestations. To facilitate the diagnosis serolo-gical screening tests are used. The authors examined in 107 children aged 10 months to 17 years IgA antibodiesagainst endomysium using a kit of Eurospital Co. (Eurospital SpA-Diagnostic division Trieste, Italia). At the timeof serum sampling for antibodies also a bioptic examination was made of the small intestine using a Watson capsuleunder skiascopic control. 51 (47.7%) of the 107 children had positive antibodies against endomysium. All childrenwith positive antibodies against endomysium had also a histological finding typical for coeliac disease. 39 (36.4%)of 107 children had negative antibodies against endomysium. 14 of them (8 children under 2 years) hada histological finding typical for coeliac disease despite the negative serological finding. Antiendomysial antibodiesare a good screening marker of coeliac disease.

Key words:
coeliac disease, antiendomysial antibodies, jejunal mucosa

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