Interleukin-1 receptor antagonist (IL-1RA) genepolymorphism in patients with ankylosing spondylitis

Czech version

Authors: J. Hrba; Š. Růžičková; J. Vencovský
Authors‘ workplace: Revmatologický ústav, Praha
Published in: Čes. Revmatol., , 2004, No. 2, p. 55-60.
Category:

Overview

Introduction.
Ankylosing spondylitis (AS) affects only a minor portion of HLA B27+ individuals.Susceptibility to AS is determined by interactions of several genes and answers best to an oligogenicepistatic model. Aim. The aim was to find out if the gene encoding for IL-1 receptor antagonist(IL-1RN) has a role in the susceptibility to AS. Methods. Two hundred and fifteen patients with AS,as well as members of 38 families, were investigated and compared with 170 healthy controls.Patients were characterized by using the Bath system. Alleles of IL-1RN gene were detected by PCR.Results. IL-1RN*2 allele frequency (24.7% vs. 15.0%; p

Key words:
ankylosing spondylitis, polymorphism of IL-1RN gene, IL-1RN*2 allele

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Article was published in

Czech Rheumatology

2004 Issue 2