Therapeutic Observational Study of Movalis in Rheumatoid Arthritis
Revmatologický ústav, Praha
Čes. Revmatol., , 2000, No. 2, p. 67-71.
The objective of this open postmarketing study is to test and express objectively the effectivenessand tolerance of meloxicam in active rheumatoid arthritis in clinical practice of out-patientrheumatologists in the Czech Republic. A total of 412 patients (76 men, 336 women) participated inthe study, mean age 53.1 (± 7) years, suffering from active rheumatoid arthritis on an average for8.6 years (± 4.3). The study lasted 8 weeks and the administered dose of meloxicam dose was 15–7.5mg per dose. At the end of the study a statistically significant improvement of all investigatedparameters of effectiveness was recorded: mean painfulness of joints at rest (p < 0.001), the meanarticular pain during movement (p = 0.01), the mean functional impairment of joints (p = 0.01), themean number of painful joints (p = 0.001), the mean number of swollen joints (p = 0.005), the meanperiod of morning stiffness (p = 0.01) and the state of the disease evaluated by the patient ( p = 0.005).The global evaluation of effectiveness by the physician was 2.13 on a four-point verbal scale (0 =poor, 3 = very good). Tolerance of treatment was very good. Undesirable effects were recorded ina total of 23 patients (5.6 %), incl. undesirable gastrointestinal effects in 13 patients (3.2%). A total of11 patients discontinued participation in the study on account of non serious undesirable gastroin-testinal effects (dyspepsia, epigastralgia), another five patients on account of other undesirableeffects (allergy, furunculosis, deterioration of another disease). Conclusion: Meloxicam in doses of7.5-15 mg per day is a very well tolerated and effective NSA in rheumatoid arthritis.
meloxicam, rheumatoid arthritis
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