New potential biomarkers for preeclampsia prediction

Authors: S. Laššáková;  M. Korabečná
Authors‘ workplace: Ústav biologie a lékařské genetiky 1. LF UK a VFN, Praha, přednosta prof. MUDr. O. Šeda, Ph. D.
Published in: Ceska Gynekol 2018; 83(6): 458-463



The review of recent literature performed with the goal to find novel biomarkers which would be able in combination with actual approaches to contribute to early pre-eclampsia (PE) detection. Attention has been paid namely to biomarkers which are detectable by methodologies of molecular genetics – microRNA (miRNA), long non-coding RNA (lncRNA) and alterations in methylation status of gene promoters with activities playing key roles in PE development.




Department of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague.


Review of articles in PubMed database published till March 2018.


In patients who developed PE, elevated levels of miR-210, miR-155, miR-16 and miR-181a were repeatedly detected. Lower values than in control subjects were found in miR-223. Exosomes represent one of the main sources of microRNA in blood – they may originate from placenta and also from blood cells themselves.

Among lncRNAs at the level of placenta tissue, the following molecules for further study were selected: LOC391533, LOC284100, CEACAMP8, RPAIN, SPRY4-IT 1 and lncRNA Uc.187 with elevated expression and MEG3, STOX2-IT3, lncRNA-ATB and MALAT-1 with decreased expression.

Alterations in promoter methylation were found also in placental tissue for examples in genes HLA-G, MTHFR, HERVWE 1, GNA12 or SERPINA3.


For all above mentioned potential biomarkers, it was possible to find the functional links to the complex process of pathogenesis of PE. With regard to the practical use, miR-210 transported in exosomes and having elevated levels in PE patients seems to be most suitable for potential widening of the recent palette of biomarkers.


pre-eclampsia, biomarkers, microRNA, long non-coding RNA, promoter methylation


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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