Erythrocyte alloimmunization in pregnant women, clinical importance and laboratory diagnostics


Authors: I. Holusková 1;  M. Lubušký 2,3;  M. Studničková 2;  M. Procházka 2
Authors‘ workplace: Transfuzní oddělení FN a LF UP, Olomouc, primářka MUDr. D. Galuszková, MBA, Ph. D. 1;  Porodnicko-gynekologická klinika FN a LF UP, Olomouc, přednosta prof. MUDr. R. Pilka, Ph. D. 2;  Ústav lékařské genetiky a fetální medicíny FN a LF UP, Olomouc, přednosta prof. MUDr. J. Šantavý, CSc. 3
Published in: Čes. Gynek.2013, 78, č. 1 s. 89-99

Overview

Objective:
The aim of this review is to give comprehensive summary of erythrocyte alloimunization of pregnant women, laboratory dignostics and clinical importance.

Design:
Review.

Setting:
University Hospital Olomouc, Transfusion Department, Department of Obstetrics and Gynecology.

Subject and method:
Based on literature analysis using database search engines PubMed, Google Scholar, Ovid in field of erythrocyte antibodies, laboratory diagnostics and clinical importance up-to-date knowledge.

Conclusion:
Erythrocyte alloimunization anti-D antibodies decreases in connection with the introduction of immunoprofylaxis. Immunization of non RhD antibodies with impossibility using of immunoprofylaxis remains still clinical problem.

Keywords:
alloimmunization – anti-D antibodies – prenatal diagnosis


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