Erythrocyte alloimmunization in pregnant women, clinical importance and laboratory diagnostics

Authors: I. Holusková 1;  M. Lubušký 2,3;  M. Studničková 2;  M. Procházka 2
Authors‘ workplace: Transfuzní oddělení FN a LF UP, Olomouc, primářka MUDr. D. Galuszková, MBA, Ph. D. 1;  Porodnicko-gynekologická klinika FN a LF UP, Olomouc, přednosta prof. MUDr. R. Pilka, Ph. D. 2;  Ústav lékařské genetiky a fetální medicíny FN a LF UP, Olomouc, přednosta prof. MUDr. J. Šantavý, CSc. 3
Published in: Ceska Gynekol 2013; 78(1): 89-99


The aim of this review is to give comprehensive summary of erythrocyte alloimunization of pregnant women, laboratory dignostics and clinical importance.


University Hospital Olomouc, Transfusion Department, Department of Obstetrics and Gynecology.

Subject and method:
Based on literature analysis using database search engines PubMed, Google Scholar, Ovid in field of erythrocyte antibodies, laboratory diagnostics and clinical importance up-to-date knowledge.

Erythrocyte alloimunization anti-D antibodies decreases in connection with the introduction of immunoprofylaxis. Immunization of non RhD antibodies with impossibility using of immunoprofylaxis remains still clinical problem.

alloimmunization – anti-D antibodies – prenatal diagnosis


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